Evidence map›Paper›PMID 41516260›Full record

ArticleInternational journal of molecular sciences2025

Liquid Chromatography with Dual Mass Spectrometry Detection: An Approach to the Determination of Br-Containing Disinfection By-Products in Drinking Water.

Sergey A Sypalov, Ilya S Varsegov, Eleonora V Danilova, Nikolay V Ulyanovskii, Dmitry S Kosyakov, Margarita Yu Vozhdaeva, Alfiya R Kholova, Dmitrii M Mazur, Albert T Lebedev

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sergey A SypalovLaboratory of Environmental Analytical Chemistry, Core Facility Center "Arktika", M.V. Lomonosov Northern (Arctic) Federal University, Northern Dvina Embankment 17, Arkhangelsk 163002, Russia.ORCID 0000-0002-2947-5099
Ilya S VarsegovLaboratory of Environmental Analytical Chemistry, Core Facility Center "Arktika", M.V. Lomonosov Northern (Arctic) Federal University, Northern Dvina Embankment 17, Arkhangelsk 163002, Russia.ORCID 0000-0003-3130-7585
Eleonora V DanilovaLaboratory of Environmental Analytical Chemistry, Core Facility Center "Arktika", M.V. Lomonosov Northern (Arctic) Federal University, Northern Dvina Embankment 17, Arkhangelsk 163002, Russia.ORCID 0009-0009-9615-2191
Nikolay V UlyanovskiiLaboratory of Environmental Analytical Chemistry, Core Facility Center "Arktika", M.V. Lomonosov Northern (Arctic) Federal University, Northern Dvina Embankment 17, Arkhangelsk 163002, Russia.ORCID 0000-0003-4796-9313
Dmitry S KosyakovLaboratory of Environmental Analytical Chemistry, Core Facility Center "Arktika", M.V. Lomonosov Northern (Arctic) Federal University, Northern Dvina Embankment 17, Arkhangelsk 163002, Russia.ORCID 0000-0001-5223-6857
Margarita Yu VozhdaevaState Unitary Enterprise "Ufavodokanal", Water Treatment Station, Rossiyskaya St. 157/2, Ufa 450098, Russia.ORCID 0000-0002-0417-074X
Alfiya R KholovaState Unitary Enterprise "Ufavodokanal", Water Treatment Station, Rossiyskaya St. 157/2, Ufa 450098, Russia.ORCID 0000-0002-1580-7857
Dmitrii M MazurFaculty of Materials Science, Shenzhen MSU-BIT University, Shenzhen 517182, China.ORCID 0000-0002-9780-1490
Albert T LebedevLaboratory of Environmental Analytical Chemistry, Core Facility Center "Arktika", M.V. Lomonosov Northern (Arctic) Federal University, Northern Dvina Embankment 17, Arkhangelsk 163002, Russia.ORCID 0000-0002-6459-9484

Funding

Russian Science Foundation 24-43-00153
6 · The paper itself

Abstract

Detecting and quantifying disinfection by-products (DBPs), especially brominated species (Br-DBPs), is analytically challenging, often necessitating multiple techniques and specific standards for each target. This complexity hinders comprehensive assessment. To overcome these limitations, we present a powerful, integrated approach combining liquid chromatography with inductively coupled plasma mass spectrometry (LC-ICP-MS) and high-resolution mass spectrometry (LC-HRMS). This method enables rapid, non-targeted group screening of Br-DBPs: LC-ICP-MS selectively identifies bromine-containing compounds, while LC-HRMS provides tentative structural identification. Crucially, this synergistic combination allows for the quantification of any Br-DBP without requiring individual reference standards. This study successfully demonstrates the application of this combined LC-ICP-MS and LC-HRMS strategy for the non-targeted detection, identification, and subsequent quantification of Br-DBPs in real drinking water samples, offering a significant advancement for DBP monitoring and risk assessment.

Indexed as

BromineDisinfectantsDisinfectionDrinking WaterLiquid Chromatography-Mass SpectrometryMass SpectrometryWater Pollutants, ChemicalChromatography, High Pressure LiquidChromatography, LiquidHalogenationWater PurificationBromineDisinfectantsDrinking WaterWater Pollutants, Chemicalaqueous chlorinationbrominated DBPsHPLC-HRMSHPLC-ICP-MS

Identifiers

PMID41516260
PMCPMC12785680

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.