Evidence map›Paper›PMID 41516226›Full record

ArticleInternational journal of molecular sciences2025

AHR Deficiency Exacerbates Hepatic Cholesterol Accumulation via Inhibiting Bile Acid Synthesis in MAFLD Rats.

Junjiu Xu, Pengwei Liu, Yuling Wu, Hongxiu He, Dandan Hu, Jianhua Sun, Jing Chen, Ying Tian, Likun Gong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Junjiu XuSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210046, China.
Pengwei LiuState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou 561113, China.
Yuling WuSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210046, China.
Hongxiu HeSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210046, China.
Dandan HuZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.
Jianhua SunCenter for Drug Safety Evaluation and Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China.
Jing ChenCenter for Drug Safety Evaluation and Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China.
Ying TianZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.ORCID 0000-0002-7683-5261
Likun GongSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210046, China.ORCID 0000-0002-1896-4188

Funding

High-level Innovative Research Institute of Department of Science and Technology of Guangdong Province 2021B0909050003
6 · The paper itself

Abstract

Metabolic-dysfunction-associated fatty liver disease (MAFLD) is a chronic liver disease characterized by abnormal lipid metabolism. The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor involved in regulating multiple physiological processes. Recent studies have demonstrated that AHR exerts a multifaceted regulatory role in liver diseases by integrating metabolic and immune signaling pathways; however, the specific role of AHR in MAFLD is not clear. In our work, a rat model of MAFLD was established by feeding wild-type (WT) and AHR knockout (AHR

Indexed as

Basic Helix-Loop-Helix ProteinsBile Acids and SaltsCholesterolFatty LiverLiverReceptors, Aryl HydrocarbonAnimalsCholesterol 7-alpha-HydroxylaseDiet, High-FatDisease Models, AnimalGastrointestinal MicrobiomeInsulin ResistanceLipid MetabolismMaleRatsRats, Sprague-DawleyAhr protein, ratBasic Helix-Loop-Helix ProteinsBile Acids and SaltsCholesterolCholesterol 7-alpha-HydroxylaseCYP7A1 protein, ratReceptors, Aryl HydrocarbonTriglyceridesAHRbile acidcholesterolgut microbiotaMAFLD

Identifiers

PMID41516226
PMCPMC12785682

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.