Evidence map›Paper›PMID 41516206›Full record

ArticleInternational journal of molecular sciences2025

Identification of Novel JAK2 Inhibitors from Amino Derivatives of Epoxyalantolactone: In Silico and In Vitro Studies.

Duangjai Todsaporn, Kamonpan Sanachai, Chanat Aonbangkhen, Rungtiva P Poo-Arporn, Victor Kartsev, Sergey Pukhov, Svetlana Afanasyeva, Athina Geronikaki, Thanyada Rungrotmongkol

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Duangjai TodsapornCenter of Excellence in Structural and Computational Biology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Kamonpan SanachaiDepartment of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0003-2605-5360
Chanat AonbangkhenCenter of Excellence in Natural Products Chemistry (CENP), Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-7378-1341
Rungtiva P Poo-ArpornBiological Engineering Program, Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand.ORCID 0000-0002-2584-9890
Victor KartsevInterBioScreen, Chernogolovka 142432, Russia.
Sergey PukhovInstitute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.
Svetlana AfanasyevaInstitute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka 142432, Russia.
Athina GeronikakiDepartment of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-9894-7777
Thanyada RungrotmongkolCenter of Excellence in Structural and Computational Biology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

Funding

Research and Innovation Fund (NSRF) B38G680006]
6 · The paper itself

Abstract

Janus kinase 2 (JAK2) is a key mediator of oncogenic signaling and a promising therapeutic target in cervical cancer. This study employed a combination of in silico and in vitro approach to discover sesquiterpene lactone (

Indexed as

Janus Kinase 2LactonesProtein Kinase InhibitorsSesquiterpenesAntineoplastic AgentsApoptosisFemaleHeLa CellsHumansMolecular Docking SimulationMolecular Dynamics SimulationReactive Oxygen SpeciesSesquiterpenes, EudesmanealantolactoneAntineoplastic AgentsJAK2 protein, humanJanus Kinase 2LactonesProtein Kinase InhibitorsReactive Oxygen SpeciesSesquiterpenesSesquiterpenes, EudesmaneJAK inhibitorkinase-targeted anticancer agentslead optimizationMD simulationsmolecular dockingsesquiterpene lactone-based scaffolds

Identifiers

PMID41516206
PMCPMC12786078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.