Evidence map›Paper›PMID 41516168›Full record

ArticleInternational journal of molecular sciences2025

Effects of Carvacrol on Oxidative Stress and Fibrosis in Streptozotocin-Induced Diabetic Nephropathy: Histological, Gene Expression, and Biochemical Insights.

Halime Tuba Canbaz, Mehmet Enes Sozen, Ilknur Cinar Ayan, Hasan Basri Savas, Furkan Adem Canbaz, Gokhan Cuce, Serpil Kalkan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Halime Tuba CanbazDepartment of Histology and Embryology, Hamidiye Faculty of Medicine, University of Health Sciences, 34668 Istanbul, Türkiye.ORCID 0000-0003-4671-1249
Mehmet Enes SozenDepartment of Histology and Embryology, Faculty of Medicine, Alanya Alaaddin Keykubat University, 07425 Antalya, Türkiye.ORCID 0000-0002-5007-6631
Ilknur Cinar AyanDepartment of Medical Biology, Faculty of Medicine, Necmettin Erbakan University, 42090 Konya, Türkiye.
Hasan Basri SavasDepartment of Medical Biochemistry, Faculty of Medicine, Mardin Artuklu University, 47200 Mardin, Türkiye.
Furkan Adem CanbazDepartment of Pediatric Urology, Sancaktepe Sehit Prof. Dr. İlhan Varank Training and Research Hospital, 34785 Istanbul, Türkiye.ORCID 0000-0002-1192-5960
Gokhan CuceDepartment of Histology and Embryology, Faculty of Medicine, Necmettin Erbakan University, 42090 Konya, Türkiye.
Serpil KalkanDepartment of Histology and Embryology, Faculty of Medicine, Necmettin Erbakan University, 42090 Konya, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) leads to renal damage through oxidative stress. Carvacrol (CAR), a monoterpenoid phenol, possesses anti-inflammatory and antioxidant properties. We investigated the potential effects of CAR on histological, gene expression, and biochemical parameters in a rat model of DM. Four groups were created: group 1, control; group 2 (

Indexed as

CymenesDiabetes Mellitus, ExperimentalDiabetic NephropathiesOxidative StressAnimalsAntioxidantsAryldialkylphosphatasebcl-2-Associated X ProteinCarboxylic Ester HydrolasesCollagen Type ICreatinineFibrosisGene Expression RegulationKidneyMaleNF-E2-Related Factor 2AntioxidantsAryldialkylphosphatasearylesteraseBax protein, ratbcl-2-Associated X ProteinCarboxylic Ester HydrolasescarvacrolCollagen Type ICreatinineCymenesNfe2l2 protein, ratNF-E2-Related Factor 2Pon1 protein, ratProto-Oncogene Proteins c-bcl-2StreptozocinUreaantioxidantcarvacroldiabetes mellitushistopathologykidney

Identifiers

PMID41516168
PMCPMC12786272

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.