Evidence map›Paper›PMID 41516165›Full record

ArticleInternational journal of molecular sciences2025

A Pilot Study of COVID-19 Outcomes in People Living with HIV in Tatarstan.

Natalya Andreeva, Svetlana Moiseeva, Alisa Garipova, Venera Shakirova, Ekaterina Martynova, Ilnur Salafutdinov, Svetlana Khaiboullina, Yuriy Davidyuk, Sinothile Khuzwayo, Ntombenhle Gama and 7 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Natalya AndreevaInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.ORCID 0009-0003-8220-6108
Svetlana MoiseevaDepartment of Infectious Diseases, Kazan State Medical Academy, 420012 Kazan, Russia.ORCID 0000-0002-6552-6068
Alisa GaripovaDepartment of Infectious Diseases, Kazan State Medical Academy, 420012 Kazan, Russia.
Venera ShakirovaDepartment of Infectious Diseases, Kazan State Medical Academy, 420012 Kazan, Russia.
Ekaterina MartynovaInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.
Ilnur SalafutdinovInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.ORCID 0000-0001-6988-0673
Svetlana KhaiboullinaInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.
Yuriy DavidyukInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.ORCID 0000-0002-4409-2942
Sinothile KhuzwayoDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Lynnwood Road, Hatfield, Pretoria 0002, South Africa.ORCID 0000-0003-0211-4565
Ntombenhle GamaDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Lynnwood Road, Hatfield, Pretoria 0002, South Africa.
Shahlo TurdikulovaCenter for Advanced Technologies, Tashkent 100174, Uzbekistan.
Dilbar DalimovaCenter for Advanced Technologies, Tashkent 100174, Uzbekistan.
Mirakbar YakubovCenter for Advanced Technologies, Tashkent 100174, Uzbekistan.ORCID 0000-0003-2928-8805
Sergey MorzunovInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.
Albert RizvanovInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.ORCID 0000-0002-9427-5739
Ilsiyar KhaertynovaDepartment of Infectious Diseases, Kazan State Medical Academy, 420012 Kazan, Russia.ORCID 0000-0001-5347-4670
Emmanuel KabweInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.ORCID 0000-0003-4328-8190

Funding

Kazan Federal University Strategic Academic Leadership Program PRIORITY-2030Ministry of Higher Education, Science, and Innovation of the Republic of Uzbekistan F-2021-156
6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic remains a significant public health threat globally with significant socio-economic impacts. People living with human immunodeficiency virus (HIV) (PLWH) have a high risk of severe outcomes of COVID-19 due to immunosuppression. Clinical manifestation of COVID-19 in HIV patients largely remains unclear. We carried out a pilot study to investigate the clinical laboratory data and circulating cytokines in PLWH infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in Tatarstan, Russia. Serum samples were collected from three groups: PLWH with COVID-19 (PLWH/COVID-19), COVID-19-only, and uninfected controls. We found an increased risk of severe COVID-19 in PLWH/COVID-19 patients compared to COVID-19-only. Four fatal cases were in PLWH/COVID-19, while there was no fatality in COVID-19-only. Pro-inflammatory cytokines, such as IL-5, IL-6, IL-9, and IL-15, were elevated in PLWH/COVID-19 compered to COVID-19-only. These preliminary findings highlight the potential for more severe COVID-19 in PLWH/COVID-19 where pro-inflammatory cytokines could play pathogenic role.

Indexed as

COVID-19HIV InfectionsAdultCytokinesFemaleHumansMaleMiddle AgedPandemicsPilot ProjectsRussiaSARS-CoV-2CytokinesCOVID-19-onlyHIVimmune responsePLWH/COVID-19SARS-CoV-2

Identifiers

PMID41516165
PMCPMC12786215

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.