Multi-Omics Integration Identifies

Wanqiu Xie, Dongfang Zhao, Henriette Franz, Annette Schmitt, Gerd Walz, Toma A Yakulov

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wanqiu XieRenal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Dongfang ZhaoRenal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Henriette FranzDepartment of Biomedicine, University of Basel, CH-4056 Basel, Switzerland.

Annette SchmittRenal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Gerd WalzRenal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Toma A YakulovRenal Division, University Freiburg Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0002-3160-0944

Funding

Deutsche Forschungsgemeinschaft CRC 1453 - Project-ID 431984000

6 · The paper itself

Abstract

Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease worldwide. However, the inflammatory mediators that causally drive disease progression remain incompletely defined. In this study, we used a multi-omics approach that combined single-cell RNA sequencing, spatial transcriptomics, pseudotime trajectory analysis, cell-to-cell communication analysis, and Mendelian randomization (MR) to investigate the role of tumor necrosis factor receptor superfamily member 1A (

Indexed as

Cellular MicroenvironmentDiabetic NephropathiesReceptors, Tumor Necrosis Factor, Type IAnimalsCell CommunicationGene Expression ProfilingHumansMultiomicsNF-kappa BSignal TransductionTranscriptomeZebrafishNF-kappa BReceptors, Tumor Necrosis Factor, Type ITNFRSF1A protein, humandiabetic kidney diseaseimmune microenvironmentinflammationMendelian randomizationNF-κB signalingsingle-cell transcriptomicsTNFRSF1Azebrafish model

Identifiers

PMID41516155

DOI10.3390/ijms27010279

PMCPMC12785335

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.