Evidence map›Paper›PMID 41516095›Full record

ArticleInternational journal of molecular sciences2025

Inhibition of PFKFB3 in Macrophages Has a Dual Effect on Tumor-Regulating Lipid Metabolism.

Elena Shmakova, Tatiana Sudarskikh, Kseniia Shalygina, Vitaliy Chagovets, Natalia Starodubtseva, Alisa Tokareva, Anastasia Novoselova, Vladimir Frankevich, Anna Tarasova, Dmitry Kostromitsky and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elena ShmakovaLaboratory of Translational Cellular and Molecular Biomedicine, National Research Tomsk State University, 634050 Tomsk, Russia.ORCID 0000-0001-6637-4417
Tatiana SudarskikhLaboratory of Translational Cellular and Molecular Biomedicine, National Research Tomsk State University, 634050 Tomsk, Russia.ORCID 0009-0001-3835-5259
Kseniia ShalyginaLaboratory of Translational Cellular and Molecular Biomedicine, National Research Tomsk State University, 634050 Tomsk, Russia.ORCID 0009-0000-6159-5173
Vitaliy ChagovetsNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia.
Natalia StarodubtsevaNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia.ORCID 0000-0001-6650-5915
Alisa TokarevaNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia.
Anastasia NovoselovaNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia.
Vladimir FrankevichNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov, Ministry of Healthcare of Russian Federation, 117997 Moscow, Russia.ORCID 0000-0002-9780-4579
Anna TarasovaAbdominal Department, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634014 Tomsk, Russia.ORCID 0000-0001-6247-3434
Dmitry KostromitskyAbdominal Department, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634014 Tomsk, Russia.ORCID 0000-0001-5691-2349
Alexey DobrodeevAbdominal Department, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634014 Tomsk, Russia.ORCID 0000-0002-2748-0644
Sergey Afanas'evAbdominal Department, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634014 Tomsk, Russia.ORCID 0000-0002-4701-0375
Irina LarionovaLaboratory of Translational Cellular and Molecular Biomedicine, National Research Tomsk State University, 634050 Tomsk, Russia.ORCID 0000-0001-5758-7330
Julia KzhyshkowskaLaboratory of Translational Cellular and Molecular Biomedicine, National Research Tomsk State University, 634050 Tomsk, Russia.ORCID 0000-0003-0898-3075

Funding

Russian Science Foundation 24-25-00455
6 · The paper itself

Abstract

Colorectal cancer is the third most common cancer worldwide, making lymph node recovery critical for treatment decisions and prognosis. Within the colorectal tumor microenvironment, the metabolic programming of tumor-associated macrophages (TAMs) can drive both pro- and anti-tumor responses, yet the specific glycolytic pathways governing their pro-metastatic conversion present promising therapeutic targets. This study investigated the role of glycolysis activating enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) in mediating TAMs metabolic polarization, and its potential as a therapeutic target. PFKFB3 expression was found to be predominant in TAMs in CRC tumor samples. Lipidomic analysis performed by HPLC-MS/MS revealed that PFKFB3 inhibition altered glycerophospholipid metabolism (

Indexed as

Colorectal NeoplasmsLipid MetabolismMacrophagesPhosphofructokinase-2Tumor-Associated MacrophagesGlycolysisHumansMetabolic ReprogrammingTumor MicroenvironmentPFKFB3 protein, humanPhosphofructokinase-2amino acid metabolismcolorectal cancerlipid metabolismPFKFB3tumor-associated macrophages

Identifiers

PMID41516095
PMCPMC12785469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.