Salts of Antifolate Pyrimethamine with Isomeric Aminobenzoic Acids: Exploring Packing Interactions and Pre-Crystallization Aggregation.

Karolina Cichocka, Magdalena Zimnicka, Karolina Kędra, Arkadiusz Gajek, Magdalena Ceborska

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Karolina CichockaFaculty of Mathematics and Natural Sciences, Cardinal Stefan Wyszyński University, 01-938 Warsaw, Poland.

Magdalena ZimnickaInstitute of Organic Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland.ORCID 0000-0001-5078-4374

Karolina KędraInstitute of Physical Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland.ORCID 0000-0002-3696-1618

Arkadiusz GajekInstitute of Physical Chemistry, Polish Academy of Sciences, 01-224 Warsaw, Poland.

Magdalena CeborskaFaculty of Mathematics and Natural Sciences, Cardinal Stefan Wyszyński University, 01-938 Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyrimethamine (PYR), a drug approved for the treatment of infections caused by protozoan parasites, is a multifunctional API based on 2,4-diaminopyrimidine scaffold. The present study aims toward the development of novel solid forms of PYR, by combining it with three isomeric aminobenzoic acids-2-aminobenzoic acid (2NH

Indexed as

AminobenzoatesPyrimethamineCalorimetry, Differential ScanningCrystallizationCrystallography, X-RaySaltsSpectroscopy, Fourier Transform InfraredX-Ray DiffractionAminobenzoatesPyrimethamineSaltsaminobenzoic acidsco-crystallizationcrystal engineeringphysicochemical propertiespyrimethamine

Identifiers

PMID41516059

DOI10.3390/ijms27010180

PMCPMC12785875

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.