Evidence map›Paper›PMID 41516023›Full record

ArticleInternational journal of molecular sciences2025

Biological Safety and Efficacy of the Novel Preservation Solution Ecosol in a Rat Liver Transplantation Model.

Kerim Yildirim, Hirokazu Tanaka, Benedict M Doorschodt, Kenji Fukushima, Shintaro Yagi, Felix Oldhafer, Oliver Beetz, Christian Bleilevens, Zoltan Czigany, Rene H Tolba

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kerim YildirimInstitute for Laboratory Animal Science and Experimental Surgery, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Hirokazu TanakaInstitute for Laboratory Animal Science and Experimental Surgery, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Benedict M DoorschodtInstitute for Laboratory Animal Science and Experimental Surgery, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Kenji FukushimaInstitute for Laboratory Animal Science and Experimental Surgery, University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0003-0305-3012
Shintaro YagiDepartment of Hepato-Biliary-Pancreatic Surgery and Transplantation/Pediatric Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8640, Japan.ORCID 0000-0001-7465-5761
Felix OldhaferDepartment of General, Visceral, Pediatric and Transplant Surgery, Faculty of Medicine, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Oliver BeetzDepartment of General, Visceral, Pediatric and Transplant Surgery, Faculty of Medicine, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Christian BleilevensDepartment of Anesthesiology, Faculty of Medicine, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Zoltan CziganyDepartment of Surgery, University of Heidelberg, 69120 Heidelberg, Germany.
Rene H TolbaInstitute for Laboratory Animal Science and Experimental Surgery, University Hospital RWTH Aachen, 52074 Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Static cold storage remains the most widely used method for organ preservation in transplantation. Over time, preservation solutions have undergone continuous optimization. Ecosol is a novel extracellular-type, colloid-based preservation solution. In this study, we evaluated the safety and efficacy of Ecosol in comparison to the gold standard University of Wisconsin (UW) solution using both allogeneic and syngeneic rat orthotopic liver transplantation models. Liver function parameters were assessed and compared to baseline values of the respective rat strains. In the syngeneic setting, alanine transaminase (ALT) levels were significantly higher in the UW group than in the Ecosol group on day 1 post-transplantation (

Indexed as

Liver TransplantationOrgan PreservationOrgan Preservation SolutionsAdenosineAlanine TransaminaseAllopurinolAnimalsAspartate AminotransferasesGlutathioneInsulinLiverL-Lactate DehydrogenaseMaleRaffinoseRatsRats, Inbred BNAdenosineAlanine TransaminaseAllopurinolAspartate AminotransferasesGlutathioneInsulinL-Lactate DehydrogenaseOrgan Preservation SolutionsRaffinoseUniversity of Wisconsin-lactobionate solutionallogenicliver transplantationorgan preservationpreservation solutionratstatic cold storagesyngeneicuniversity of wisconsin

Identifiers

PMID41516023
PMCPMC12786024

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.