Evidence map›Paper›PMID 41515989›Full record

ArticleInternational journal of molecular sciences2025

Features of Mitochondrial Dynamics in Different Brain Parts of Patients with Alzheimer's Disease.

Vladimir S Sukhorukov, Tatiana I Baranich, Olga V Velts, Dmitry N Voronkov, Ekaterina V Shcherbak, Dmitry S Lazarev, Dmitry A Kharlamov, Alexandr P Raksha

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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vladimir S SukhorukovLaboratory of Neuromorphology, Russian Center of Neurology and Neurosciences, 125367 Moscow, Russia.ORCID 0000-0002-0552-6939
Tatiana I BaranichLaboratory of Neuromorphology, Russian Center of Neurology and Neurosciences, 125367 Moscow, Russia.
Olga V VeltsLaboratory of Neuromorphology, Russian Center of Neurology and Neurosciences, 125367 Moscow, Russia.ORCID 0009-0003-0223-7335
Dmitry N VoronkovLaboratory of Neuromorphology, Russian Center of Neurology and Neurosciences, 125367 Moscow, Russia.ORCID 0000-0001-5222-5322
Ekaterina V ShcherbakPirogov City Clinical Hospital No. 1, 119049 Moscow, Russia.
Dmitry S LazarevDepartment of Morphology, Pirogov Russian National Research Medical University, 117513 Moscow, Russia.
Dmitry A KharlamovVoyno-Yasenetsky Scientific and Practical Center of Specialized Medical Care for Children, 119620 Moscow, Russia.
Alexandr P RakshaPirogov City Clinical Hospital No. 1, 119049 Moscow, Russia.

Funding

Ministry of Education of Russia for large-scale scientific projects in priority areas of scientific and technological development Agreement No. 075 - 15 - 2024 - 638
6 · The paper itself

Abstract

A number of recent studies have demonstrated the importance of investigating mitochondrial dynamics mechanisms in Alzheimer's disease (AD). This study involved an immunohistochemical analysis of mitochondrial dynamics markers Opa-1, Mfn-2, and Drp-1 in neurons of the middle frontal gyrus, anterior cingulate gyrus, head of the caudate nucleus, hippocampus, and inferior parietal lobule using autopsy material from AD patients. The comparison was made with similar brain regions in autopsy material from elderly and young patients. Additionally, changes in these markers in AD were correlated with the distribution of pathological amyloid aggregates in the corresponding regions. Our findings suggest specific features of metabolic process alterations in neurons in AD, which are not limited to a single brain region but involve multiple areas and exhibit a uniform pattern. Our data are significant for understanding the pathogenesis of this disease and aging in general, and may serve as a basis for developing targeted therapy for AD.

Indexed as

Alzheimer DiseaseBrainMitochondrial DynamicsAdultAgedAged, 80 and overBiomarkersDynaminsFemaleGTP PhosphohydrolasesHippocampusHumansMaleMiddle AgedMitochondriaMitochondrial ProteinsBiomarkersDNM1L protein, humanDynaminsGTP PhosphohydrolasesMFN2 protein, humanMitochondrial ProteinsOPA1 protein, humanagingAlzheimer’s diseaseamyloidhippocampusmitochondrial dynamicsneuron

Identifiers

PMID41515989
PMCPMC12785407

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.