Evidence map›Paper›PMID 41515981›Full record

ReviewInternational journal of molecular sciences2025

Cochlear Homeostasis in Sensorineural Hearing Loss: Mechanisms, Implications, and Therapeutic Prospects.

Srdjan M Vlajkovic, Haruna Suzuki-Kerr, Bryony A Nayagam

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Recent Progress in Mechanism-Based Therapies forInternational journal of molecular sciences · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Srdjan M VlajkovicDepartment of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand.ORCID 0000-0001-8548-6844
Haruna Suzuki-KerrDepartment of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand.ORCID 0000-0002-4860-3527
Bryony A NayagamDepartment of Audiology and Speech Pathology, The University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0003-1069-6059

Funding

MBIE New Zealand PROP-1574-ENDRP-UOA
6 · The paper itself

Abstract

Cochlear homeostasis is critical for the preservation of hearing sensitivity by maintaining optimal cochlear fluid composition, sustaining electrochemical gradients, and supporting the function of sensory and supporting cells in the cochlea. Sensorineural hearing loss, resulting from the damage or loss of sensory hair cells, auditory neurons and other cochlear cells and structures, is intimately linked to disruptions in the homeostatic environment. In this narrative review, we explore the cellular and molecular pathways underpinning cochlear homeostasis in health and disease and examine the mechanisms by which failed homeostasis leads to sensorineural hearing loss. We further discuss current research avenues and emerging therapeutic strategies to restore or compensate for the loss of homeostatic balance. These interventions suggest a future where regenerative healing is possible, ultimately leading to permanent repair and functional recovery.

Indexed as

CochleaHearing Loss, SensorineuralHomeostasisAnimalsHair Cells, AuditoryHumanscochleagene therapyhomeostasisregenerative medicinesensorineural hearing lossstria vascularis

Identifiers

PMID41515981
PMCPMC12786260

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.