Evidence map›Paper›PMID 41515933›Full record

ArticleInternational journal of molecular sciences2025

Oct4 Contributes to Mesodermal Differentiation by Sustaining the Proliferative Capacity of Early Mesodermal Progenitors.

Anastasiia V Lukacheva, Anna S Zinovyeva, Andrey A Kuzmin, Mikhail N Gordeev, Vladislav V Vasilin, Daria V Kriger, Nikolay D Aksenov, Alexey N Tomilin, Evgeny I Bakhmet

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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anastasiia V LukachevaInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Anna S ZinovyevaInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.ORCID 0009-0002-1572-4709
Andrey A KuzminInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Mikhail N GordeevInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Vladislav V VasilinInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.ORCID 0009-0008-9006-4425
Daria V KrigerInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.ORCID 0000-0002-7147-1884
Nikolay D AksenovInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.ORCID 0000-0002-2549-9149
Alexey N TomilinInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.ORCID 0000-0002-1137-7167
Evgeny I BakhmetInstitute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.ORCID 0000-0002-9499-4151

Funding

Russian Science Foundation 23-75-10096
6 · The paper itself

Abstract

Oct4 is well established as a core regulator of pluripotency, yet emerging evidence points to an additional role in lineage specification during the exit from the pluripotent state. Although Oct4 expression has been observed in early mesodermal progenitors, its precise function in this developmental context remains unclear. To investigate this, we employed embryoid bodies (EBs) as a model of spontaneous differentiation that recapitulates key aspects of early embryonic development in vitro. In accordance with previous studies, reporter assay revealed a distinct temporal pattern characterized by the strong, transient co-expression of

Indexed as

Cell DifferentiationMesodermOctamer Transcription Factor-3AnimalsBrachyury ProteinCell LineageCell ProliferationEmbryoid BodiesFetal ProteinsGene Expression Regulation, DevelopmentalHepatocyte Nuclear Factor 3-betaHMGB ProteinsMiceSOXF Transcription FactorsT-Box Domain ProteinsBrachyury ProteinFetal ProteinsFoxa2 protein, mouseHepatocyte Nuclear Factor 3-betaHMGB ProteinsOctamer Transcription Factor-3Pou5f1 protein, mouseSox17 protein, mouseSOXF Transcription FactorsT-Box Domain Proteinscell proliferationembryoid bodieslineage specificationmesodermal differentiationOct4pluripotency

Identifiers

PMID41515933
PMCPMC12786243

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.