Evidence map›Paper›PMID 41515900›Full record

ArticleInternational journal of molecular sciences2025

Integrating Bioinformatics and Experimental Validation Identifies SCD as a Ferroptosis-Related Immune Regulator and Therapeutic Target in Crohn's Disease.

Jingtong Wu, Lixiang Zhou, Dongmei Qiu, Tao Wei, Chaohui Xie, Ermei Chen, Mengjie Lin, Yanyun Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jingtong WuDepartment of Gastroenterology, Clinical Research Center for Gut Microbiota and Digestive Diseases of Fujian Province, The National Key Clinical Specialty, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361004, China.
Lixiang ZhouDepartment of Gastroenterology, Clinical Research Center for Gut Microbiota and Digestive Diseases of Fujian Province, The National Key Clinical Specialty, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361004, China.
Dongmei QiuDepartment of Gastroenterology, Clinical Research Center for Gut Microbiota and Digestive Diseases of Fujian Province, The National Key Clinical Specialty, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361004, China.
Tao WeiDepartment of Digestive Disease, Institute for Microbial Ecology, School of Medicine, Xiamen University, Xiamen 361004, China.
Chaohui XieDepartment of Gastroenterology, Clinical Research Center for Gut Microbiota and Digestive Diseases of Fujian Province, The National Key Clinical Specialty, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361004, China.
Ermei ChenDepartment of Gastroenterology, Clinical Research Center for Gut Microbiota and Digestive Diseases of Fujian Province, The National Key Clinical Specialty, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361004, China.
Mengjie LinDepartment of Pathology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361004, China.
Yanyun FanDepartment of Gastroenterology, Clinical Research Center for Gut Microbiota and Digestive Diseases of Fujian Province, The National Key Clinical Specialty, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361004, China.

Funding

the Natural Science Foundation of Fujian Province 2025J011410the Natural Science Foundation of Fujian Province 2025J08298
6 · The paper itself

Abstract

This study investigates the role of ferroptosis-related genes (FRGs) in the intestinal inflammation of Crohn's disease (CD). Through integrated bioinformatics and experimental validation, we identified differentially expressed genes from RNA-seq data and intersected them with known FRGs to obtain ferroptosis-related differentially expressed genes (FEDGs). Functional enrichment and immune infiltration analyses were performed, and seven hub FEDGs were selected using machine learning. A diagnostic model based on these genes showed strong predictive ability. Immune analysis revealed significant associations with macrophages, neutrophils, dendritic cells, and CD4+ T cells. Protein expression of key hub genes was validated in clinical CD samples and a DSS-induced colitis model. Importantly, localized inhibition of SCD alleviated disease severity in experimental colitis. These findings highlight the involvement of ferroptosis in CD immune dysregulation and propose SCD as a potential therapeutic target.

Indexed as

Computational BiologyCrohn DiseaseFerroptosisAnimalsGene Expression ProfilingGene Expression RegulationHumansMiceCrohn’s disease (CD)differentially expressed genes (DEGs)ferroptosisferroptosis-related DEGs (FEDGs)immune infiltrationStearoyl coenzyme A desaturase

Identifiers

PMID41515900
PMCPMC12786048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.