Chemoselectively Functionalized Ketoesters by Halogenative C-C Bond Cleavage of Cyclic Diketones.

Hideyasu China, Nami Kageyama, Hodaka Yatabe, Mihoyo Fujitake, Yusei Matsumoto, Zhihan Jing, Toshifumi Dohi

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Hideyasu ChinaFaculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, 97-1, Minamihokotate, Kodo, Kyotanabe 610-0395, Kyoto, Japan.

Nami KageyamaCollege of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu 525-8577, Shiga, Japan.

Hodaka YatabeCollege of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu 525-8577, Shiga, Japan.

Mihoyo FujitakeCenter for Pharmaceutical Research and Development, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki 569-1094, Osaka, Japan.

Yusei MatsumotoCollege of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu 525-8577, Shiga, Japan.

Zhihan JingCollege of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu 525-8577, Shiga, Japan.ORCID 0009-0002-4250-6336

Toshifumi DohiCollege of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu 525-8577, Shiga, Japan.ORCID 0000-0002-2812-9581

Funding

JSPS KAKENHI 24K09738JST CREST grant JPMJCR20R1

6 · The paper itself

Abstract

Haloketoesters are synthetic intermediates in various cyclization reactions that facilitate the production of biologically active compounds. Nonetheless, the selective synthesis of dihaloketoesters and trihaloketoesters, which are expected to be highly versatile, presents significant challenges. In this study, we designed a new synthetic approach that selectively and efficiently produces haloketoesters through the halogenative C-C bond cleavage and ring-opening reactions of cyclic 1,3-diketones. This convenient method enables the direct synthesis of di- and trichloro-functionalized ketoesters from 1,3-cyclohexadiones under mild conditions. Na

Indexed as

C–C bond cleavagecyclic diketonefunctionalizationhalogenationketoestersring-opening reaction

Identifiers

PMID41515494

DOI10.3390/molecules31010199

PMCPMC12787718

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