Evidence map›Paper›PMID 41515456›Full record

ArticleMolecules (Basel, Switzerland)2026

Synthesis, Crystal Structure, Antitumor, and Antimicrobial Activity of Novel Copper(II) Complexes with a Coumarin Derivative Containing a Histamine Substituent.

Ewelina Namiecińska, Pawel Hikisz, Patryk Czapnik, Magdalena Małecka, Magdalena Grazul, Peter Mayer, Ingo-Peter Lorenz, Elzbieta Budzisz

Abstract read
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In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ewelina NamiecińskaDepartment of the Chemistry of Cosmetic Raw Materials, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.ORCID 0000-0002-3626-9357
Pawel HikiszDepartment of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Patryk CzapnikDepartment of Physical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163/165, 90-236 Lodz, Poland.
Magdalena MałeckaDepartment of Physical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163/165, 90-236 Lodz, Poland.ORCID 0000-0003-3384-9855
Magdalena GrazulDepartment of Pharmaceutical Microbiology and Microbiological Diagnostics, Faculty of Pharmacy, Medical University of Lodz, Muszynski 1 street, 90-151 Lodz, Poland.
Peter MayerDepartment of Chemistry and Biochemistry, Ludwig Maximilians University, Butenandtstr. 5-13 (D), D-81377 Munich, Germany.
Ingo-Peter LorenzDepartment of Chemistry and Biochemistry, Ludwig Maximilians University, Butenandtstr. 5-13 (D), D-81377 Munich, Germany.
Elzbieta BudziszDepartment of the Chemistry of Cosmetic Raw Materials, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.ORCID 0000-0001-9949-8723

Funding

Medical University of Lodz 503/3-066-02/503-31-001
6 · The paper itself

Abstract

Copper(II) complexes have great potential as antitumor and antimicrobial agents, and their coumarin derivatives bearing histamine substituents possess versatile structural and biological properties. The present article describes the synthesis of novel copper(II)-coumarin-histamine complexes and ligands and their characterization by IR, NMR, X-ray diffraction, and elemental analysis. Their antimicrobial activity (MIC, MBC/MFC) was tested against 11 reference strains. Cytotoxicity was evaluated using the MTT assay against 15 selected cancer cell lines and normal HMEC-1 cells. It presents three new ligands and three new complexes with copper(II) ions and selected histamine-containing coumarin derivatives. The new copper(II) complexes demonstrated markedly higher anticancer activity than their corresponding ligands across all evaluated cancer cell lines. The highest anticancer activity against the Hep3B liver cancer cell line was demonstrated by the copper(II) complex (

Indexed as

Anti-Infective AgentsAntineoplastic AgentsCoordination ComplexesCopperCoumarinsHistamineAnti-Bacterial AgentsCell Line, TumorCrystallography, X-RayHumansMicrobial Sensitivity TestsMolecular StructureStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective AgentsAntineoplastic AgentsCoordination ComplexesCoppercoumarinCoumarinsHistamineanticancer propertiescopper(II) complex with coumarin ligandscrystal structuresflavonoid derivatives

Identifiers

PMID41515456
PMCPMC12788114

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