Evidence map›Paper›PMID 41515279›Full record

ArticleNutrients2026

Dietary Patterns Are Associated with Blood Cell Profiles and the Molecular Composition of Platelet-Rich Plasma.

Hadrian Platzer, Alena Bork, Simone Gantz, Baraa Khamees, Maciej J K Simon, Sébastien Hagmann, Yannic Bangert, Babak Moradi

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In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hadrian PlatzerDepartment of Orthopedics and Trauma Surgery, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3, 24105 Kiel, Germany.ORCID 0000-0001-9805-3810
Alena BorkDepartment of Orthopedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118 Heidelberg, Germany.
Simone GantzOrthopedic Research Center, Kiel University, Michaelisstr. 5, 24105 Kiel, Germany.ORCID 0009-0006-2075-9550
Baraa KhameesDepartment of Orthopedics and Trauma Surgery, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3, 24105 Kiel, Germany.ORCID 0009-0009-5701-4028
Maciej J K SimonDepartment of Orthopedics and Trauma Surgery, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3, 24105 Kiel, Germany.
Sébastien HagmannDepartment of Orthopedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118 Heidelberg, Germany.ORCID 0000-0003-1671-2494
Yannic BangertDepartment of Orthopedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118 Heidelberg, Germany.ORCID 0000-0001-8392-7829
Babak MoradiDepartment of Orthopedics and Trauma Surgery, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3, 24105 Kiel, Germany.ORCID 0000-0003-1714-2171

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesPlatelet-rich plasma (PRP) is increasingly used in musculoskeletal medicine. Variability in PRP composition, driven by preparation- and donor-related factors, is considered a major contributor to inconsistent clinical outcomes. This study investigated whether habitual dietary patterns are associated with the cellular and molecular composition of leukocyte-poor PRP (LP-PRP).

methodsIn this cross-sectional study, 75 healthy adults (25 vegans, 25 vegetarians, and 25 omnivores) who adhered to their dietary patterns for ≥6 months were enrolled. LP-PRP was prepared by a standardized protocol. Cell profiles were quantified in whole blood and LP-PRP; LP-PRP proteins (IL-6, IGF-1, HGF, and PDGF-BB) were measured by ELISA. Group differences, correlations, and multivariable regressions were performed.

resultsWhole blood differed by diet with respect to total leukocytes, lymphocytes, and basophils, while platelet and erythrocyte counts did not. In LP-PRP, platelet enrichment ratios and leukocyte counts were comparable across diets. IL-6 in LP-PRP was lower in vegans vs. omnivores (

conclusionsDietary patterns were associated with selected molecular components of LP-PRP-most consistently IL-6-while cell counts remain largely unchanged. However, interventional studies are needed to establish causality and determine whether dietary modification can influence clinical outcomes.

Indexed as

Blood CellsDietPlatelet-Rich PlasmaAdultBecaplerminCross-Sectional StudiesDiet, VeganDiet, VegetarianFemaleHepatocyte Growth FactorHumansInsulin-Like Growth Factor IInterleukin-6MaleMiddle AgedProto-Oncogene Proteins c-sisBecaplerminHepatocyte Growth FactorHGF protein, humanIL6 protein, humanInsulin-Like Growth Factor IInterleukin-6Proto-Oncogene Proteins c-siscytokinedietary patterngrowth factorinflammationosteoarthritisplatelet-rich plasmaregenerative therapies

Identifiers

PMID41515279
PMCPMC12787948

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