Evidence map›Paper›PMID 41514706›Full record

ArticleAnimals : an open access journal from MDPI2025

High Doses of Norfloxacin Nicotinate Induce Apoptosis, Developmental Neurotoxicity, and Aberrant DNA Methylation in Zebrafish (

Hansun Fang, Runping Wang, Fang Wang, Kaibin Li, Huili Liang, Tian Su, Lili Wei, Jiming Ruan, Fugui Li, Ximei Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hansun FangKey Laboratory of Poyang Lake Basin Agricultural Resource and Ecology of Jiangxi Province, College of Land Resource and Environment, Jiangxi Agricultural University, Nanchang 330045, China.
Runping WangCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Fang WangPearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510380, China.
Kaibin LiPearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510380, China.
Huili LiangPearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510380, China.
Tian SuJiangxi Center Station of Irrigation Experiment, Nanchang 330201, China.
Lili WeiCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Jiming RuanCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Fugui LiCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Ximei LiangCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.ORCID 0000-0002-9025-6602

Funding

the Key Technology Research and Development Project of Jiangxi Provincial Department of Agriculture and Rural Affairs 2023yyzygg-05，2022yyzygg-03, and 2025yyzygg-05the National Natural Science Foundation of China (42367062)the Natural Science Foundation of Jiangxi Province 20202BABL205006the Science and Technology Project of Jiangxi Provincial Education Department GJJ180186
6 · The paper itself

Abstract

This study aimed to evaluate the response mechanisms of zebrafish larvae to Norfloxacin nicotinate (NOR-N) exposure. Embryos were exposed to NOR-N from 4 h post-fertilization (hpf) until 96 hpf. The exposure concentrations included 0.002, 0.2, 1, and 5 mg/L (simulating both normal and exceptionally high environmentally relevant levels of NOR), as well as a high dose of 25 mg/L. Subsequent analyses focused on apoptosis, neurodevelopment, and DNA methylation in the resulting zebrafish larvae. The results showed that high-dose NOR-N (≥5 mg/L) induced obvious apoptotic cell death in zebrafish larvae, accompanied by increased activities of Cas3 and Cas9, up-regulated

Indexed as

apoptosisdevelopmental neurotoxicityDNA methylationnorfloxacin nicotinatezebrafish

Identifiers

PMID41514706
PMCPMC12784661

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.