Evidence map›Paper›PMID 41514704›Full record

ArticleAnimals : an open access journal from MDPI2025

Dietary Oligosaccharides Alter Blood and Fecal Metabolites in Holstein Dairy Calves.

Rafaela Santos, Luciana M Kluppel, Nirosh Senevirathne, Juliano Peres Prietsch, Venkateswarlu Sunkesula, Olufemi Akinkuotu, Babafela Awosile, Erminio Trevisi, Fernanda Rosa

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rafaela SantosSchool of Veterinary Medicine, Texas Tech University, Amarillo, TX 79106, USA.
Luciana M KluppelSchool of Veterinary Medicine, Texas Tech University, Amarillo, TX 79106, USA.
Nirosh SenevirathneDepartment of Animal Sciences, Cornell University, Ithaca, NY 14850, USA.ORCID 0000-0002-5676-4785
Juliano Peres PrietschSchool of Veterinary Medicine, Texas Tech University, Amarillo, TX 79106, USA.ORCID 0009-0003-1427-7617
Venkateswarlu SunkesulaIdaho Milk Products, Jerome, ID 83338, USA.ORCID 0000-0003-4561-819X
Olufemi AkinkuotuSchool of Veterinary Medicine, Texas Tech University, Amarillo, TX 79106, USA.
Babafela AwosileSchool of Veterinary Medicine, Texas Tech University, Amarillo, TX 79106, USA.ORCID 0000-0002-4779-6515
Erminio TrevisiDepartment of Animal Sciences, Food and Nutrition (DIANA), Faculty of Agriculture, Food and Environmental Science, Università Cattolica del Sacro Cuore, 20123 Milan, Italy.ORCID 0000-0003-1644-1911
Fernanda RosaSchool of Veterinary Medicine, Texas Tech University, Amarillo, TX 79106, USA.ORCID 0000-0002-8906-4056

Funding

Idaho Milk Products N/ATexas Tech University N/A
6 · The paper itself

Abstract

Neonatal and weaning periods are the most challenging phases for enteric infections in dairy calves. While different approaches are used to minimize calf health issues, the neonatal diet remains the core approach to enhance pre- and post-weaning animal health and performance. This pilot study aimed to evaluate blood biomarkers of inflammation and fecal metabolites in calves supplemented with oligosaccharide mixture (OS) during the preweaning stage. Sixteen newborn Holstein dairy calves (eight females and eight males) were randomly assigned into two groups: control with no supplementation, or treatment with 50 g/day of OS added to the pasteurized waste milk feeding. Both control and OS-treated calves were fed pasteurized waste milk during the preweaning period and weaned at seven weeks of age. Blood and fecal samples were collected weekly. Fecal fatty acid metabolites were downregulated in treated calves compared to control calves (

Indexed as

dairy calveshealthmetabolitesoligosaccharidespreweaning

Identifiers

PMID41514704
PMCPMC12785019

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.