Evidence map›Paper›PMID 41514633›Full record

ArticleCancers2025

High-Dose Methotrexate at All Ages: Safety, Efficacy, and Outcomes from the HDMTX European Registry.

Bertrand Pourroy, Maria D Aumente, Christian Koenecke, Martin Stanulla, Andrés J M Ferreri, Thais Murciano-Carillo, Madhumita Dandapani, Timothy A Ritzmann, Pere Barba, Etienne Chatelut and 13 more

Erratum issuedAbstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Bertrand PourroyOncopharma Unit, Hôpitaux Universitaires de Marseille La Timone, 13005 Marseille, France.ORCID 0000-0002-2388-3518
Maria D AumentePharmacy Service, Reina Sofia University Hospital, 14004 Cordoba, Spain.ORCID 0000-0002-7584-924X
Christian KoeneckeDepartment of Pediatric Hematology and Oncology, University of Hannover, 30167 Hannover, Germany.ORCID 0000-0001-7025-1735
Martin StanullaDepartment of Pediatric Hematology and Oncology, University of Hannover, 30167 Hannover, Germany.ORCID 0000-0002-3834-0727
Andrés J M FerreriLymphoma Unit, IRCCS San Raffaele Scientific Institute, 20132 Milano, Italy.ORCID 0000-0001-9606-6124
Thais Murciano-CarilloPediatric Oncology & Hematology, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.ORCID 0000-0001-8659-1603
Madhumita DandapaniDepartment of Pediatrics Oncology/Haematology, University of Nottingham, Nottingham NG5 1PB, UK.ORCID 0000-0001-8444-6007
Timothy A RitzmannChildren's Brain Tumour Research Centre, University of Nottingham, Nottingham NG7 2UH, UK.ORCID 0000-0002-4438-6588
Pere BarbaHematology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.ORCID 0000-0001-7076-7969
Etienne ChatelutDepartment of Pharmacology, Institut Universitaire du Cancer-Oncopole, 31059 Toulouse, France.ORCID 0000-0002-7740-9096
Katrina M IngleySarcoma Department, University College London Hospital, London NW1 2PB, UK.ORCID 0000-0002-1806-2686
Emma MorrisPharmacy Cancer Services, University College London Hospital, London NW1 2PB, UK.ORCID 0009-0003-6234-7878
Elisabeth SchorbComprehensive Cancer Center, University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0003-0948-2125
Sven LiebigDepartment of Hematology, Oncology and Tumor Immunology, Charite Universitätsmedizin, 10117 Berlin, Germany.ORCID 0000-0002-5494-8476
Stefan SchwartzDepartment of Hematology, Oncology and Tumor Immunology, Charite Universitätsmedizin, 10117 Berlin, Germany.ORCID 0000-0001-8833-5793
Scott C HowardResonance, Memphis, TN 38104, USA.ORCID 0000-0003-2244-1686
Ryan CombsResonance, Memphis, TN 38104, USA.ORCID 0000-0001-8795-4859
Nicolás TentoniResonance, Memphis, TN 38104, USA.ORCID 0000-0002-9402-5086
Jennifer LoweResonance, Memphis, TN 38104, USA.ORCID 0009-0001-3975-6214
Gabriela VillanuevaResonance, Memphis, TN 38104, USA.ORCID 0000-0002-6159-1882
Claudia SamporResonance, Memphis, TN 38104, USA.
Miriam HwangResonance, Memphis, TN 38104, USA.ORCID 0000-0002-0685-4352
Carmelo RizzariDepartment of Pediatrics, University of Milano-Bicocca, 20126 Milan, Italy.ORCID 0000-0002-4828-3893

Funding

BTG 30_003629 (See COI notes above)
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acute kidney injuryclinical outcomesdelayed methotrexate eliminationhigh-dose methotrexate

Identifiers

PMID41514633
PMCPMC12784913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.