Evidence map›Paper›PMID 41514626›Full record

ArticleCancers2025

Hypoxia-Inducible Factor-1α, a Novel Molecular Target for a 2-Aminopyrrole Derivative: Biological and Molecular Modeling Study.

Svetlana S Zykova, Tatyana Gessel, Aigul Galembikova, Evgenii S Mozhaitsev, Sophia S Borisevich, Nazim Igidov, Emiliya S Egorova, Ekaterina Mikheeva, Natalia Khromova, Pavel Kopnin and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Svetlana S ZykovaPerm State Pharmaceutical Academy, Perm 614990, Russia.
Tatyana GesselDepartment of Pathology, Kazan State Medical University, Kazan 420012, Russia.ORCID 0009-0003-4348-9141
Aigul GalembikovaDepartment of Pathology, Kazan State Medical University, Kazan 420012, Russia.ORCID 0000-0002-0293-2974
Evgenii S MozhaitsevN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.ORCID 0000-0002-5344-9499
Sophia S BorisevichUfa Institute of Chemistry, Ural Federal Research Center, Russian Academy of Sciences, Ufa 450054, Russia.ORCID 0000-0001-8481-0470
Nazim IgidovPerm State Pharmaceutical Academy, Perm 614990, Russia.
Emiliya S EgorovaCentral Research Laboratory, Kazan State Medical University, Kazan 420012, Russia.ORCID 0000-0002-6210-4660
Ekaterina MikheevaDepartment of Pathology, Kazan State Medical University, Kazan 420012, Russia.ORCID 0000-0001-8213-427X
Natalia KhromovaCytogenetics Laboratory, Carcinogenesis Institute, N.N. Blokhin National Medical Research Center of Oncology, Moscow 115478, Russia.
Pavel KopninCytogenetics Laboratory, Carcinogenesis Institute, N.N. Blokhin National Medical Research Center of Oncology, Moscow 115478, Russia.ORCID 0000-0002-2078-4274
Alina GalyautdinovaDepartment of Pathology, Kazan State Medical University, Kazan 420012, Russia.ORCID 0009-0003-0885-5994
Vladimir LuzhaninPerm State Pharmaceutical Academy, Perm 614990, Russia.ORCID 0000-0002-6312-2027
Maxim ShustovPerm State Pharmaceutical Academy, Perm 614990, Russia.ORCID 0000-0002-3379-3065
Sergei BoichukDepartment of Pathology, Kazan State Medical University, Kazan 420012, Russia.ORCID 0000-0003-2415-1084

Funding

Ministry of Health of the Russian Federation ZUNI-2025-0004 "Development of targeted drug candidates with high cytotoxic and antitumor activity based on 2-aminopyrrolesRussian Science Foundation 25-15-00086
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

2-aminopyrrolesapoptosisfoldingheterocyclesHIF-1αmolecular dockingproliferationtumor growth

Identifiers

PMID41514626
PMCPMC12784696

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.