Evidence map›Paper›PMID 41514599›Full record

ReviewCancers2025

Cellular Senescence as a Risk Factor in Head and Neck Cancer-Diagnostic and Therapeutic Perspective.

Magdalena Stachowiak, Magdalena Kostrzewa, Wojciech Golusinski, Pawel Golusinski, Ewelina Golusinska-Kardach, Michal M Masternak, Błażej Rubiś

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Magdalena StachowiakDepartment of Head and Neck Surgery, Poznan University of Medical Sciences, 61-701 Poznan, Poland.ORCID 0009-0009-0893-3722
Magdalena KostrzewaDepartment of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, 60-806 Poznan, Poland.ORCID 0009-0008-5671-3348
Wojciech GolusinskiDepartment of Head and Neck Surgery, Poznan University of Medical Sciences, 61-701 Poznan, Poland.ORCID 0000-0002-6075-3464
Pawel GolusinskiDepartment of Otolaryngology and Maxillofacial Surgery, University of Zielona Gora, 65-417 Zielona Gora, Poland.ORCID 0000-0002-3937-5315
Ewelina Golusinska-KardachDepartment of Dental Surgery, Periodontology and Oral Mucosa Diseases, Poznan University of Medical Sciences, 60-812 Poznan, Poland.ORCID 0000-0002-9520-2670
Michal M MasternakDepartment of Head and Neck Surgery, Poznan University of Medical Sciences, 61-701 Poznan, Poland.ORCID 0000-0002-8483-930X
Błażej RubiśDepartment of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, 60-806 Poznan, Poland.ORCID 0000-0003-1730-0176

Funding

National Science Centre 2023/49/B/NZ7/00744National Science Centre 2023/51/B/NZ5/00498
6 · The paper itself

Abstract

Head and neck cancer (HNC) affects nearly 1 million people every year. The main risk factors include tobacco, alcohol, or human papilloma virus (HPV) viral infections, which contribute to HNC development through various, mostly unknown, mechanisms. One of these postulated mechanisms is cellular senescence. This biological aging-associated process is responsible not only for the arrest of cellular growth and division but also mediates the modulation of cell metabolism and secretory phenotype. Consequently, it may play a crucial role in carcinogenesis, which makes it an interesting topic in the context of cancer development, prognosis, prevention, and therapy. This review focuses on the current state of knowledge regarding all aspects of the association between cellular senescence and head and neck cancer.

Indexed as

head and neck cancerHNC diagnosticsHNC risk factorsHNC therapysenescence

Identifiers

PMID41514599
PMCPMC12784665

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.