Evidence map›Paper›PMID 41514514›Full record

ArticleCancers2025

Response Prediction of Chemoradiotherapy for Rectal Cancer Using Rapid Semi-Automated Flow Cytometry.

Hiroyuki Amagai, Koichi Hayano, Takahiro Shioyama, Akane Suzuki, Gaku Ohira, Tetsuro Maruyama, Toru Tochigi, Koichiro Okada, Takahiro Arasawa, Nobufumi Sekino and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hiroyuki AmagaiDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.
Koichi HayanoDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.
Takahiro ShioyamaNihon Kohden Corporation, Tokyo 161-8560, Japan.
Akane SuzukiNihon Kohden Corporation, Tokyo 161-8560, Japan.
Gaku OhiraDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.
Tetsuro MaruyamaDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.
Toru TochigiDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.ORCID 0000-0002-8734-3975
Koichiro OkadaDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.ORCID 0000-0001-6443-3882
Takahiro ArasawaDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.
Nobufumi SekinoDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.
Ryoya MizumachiDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.ORCID 0000-0002-2255-0869
Soichiro HirasawaDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.
Masaya UesatoDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.
Michihiro MaruyamaDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.
Yoshihiro KurataDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.
Atsushi HirataDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.ORCID 0000-0001-5931-7596
Hisahiro MatsubaraDepartment of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba City 260-8670, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: The effectiveness of chemoradiotherapy (CRT) for rectal cancer varies greatly among patients, and no reliable biomarker for predicting treatment response currently exists. We investigated whether cell cycle analysis using rapid semi-automated flow cytometry could predict the effectiveness of CRT. (2) Methods: This prospective study included 32 patients with rectal cancer undergoing CRT. The cell cycle of biopsy specimens from rectal cancer patients before CRT was semi-automatically and rapidly analyzed using Celltac PEAK as flow cytometer. The proportion of cell cycle phases is compared with treatment response after CRT. (3) Results: Patients with a tumor reduction rate ≥ 30% on CT showed a significantly higher proportion of cells in the Over G2/M phase compared with those with <30% reduction (median 2.45% vs. 0.95%,

Indexed as

chemoradiationflow cytometryrectal cancer

Identifiers

PMID41514514
PMCPMC12784879

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.