Evidence map›Paper›PMID 41514481›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Immunoaffinity-Mimetic Assembly of Peptide-Aptamer Conjugates and Stem Cell-Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair.

Dantong Zheng, Yuxin Bai, Zhibo Liu, Zinan Zhao, Yiming Kong, Yao Xu, Qi Jia, Rongrong Zhu, Yong Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dantong ZhengDepartment of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-1994-0540
Yuxin BaiDepartment of Orthopedics, School of Life Sciences and Technology, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Tongji Hospital Affiliated to Tongji University, Tongji University, Shanghai, China.
Zhibo LiuDepartment of Orthopedics, School of Life Sciences and Technology, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Tongji Hospital Affiliated to Tongji University, Tongji University, Shanghai, China.
Zinan ZhaoDepartment of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai, China.
Yiming KongDepartment of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai, China.
Yao XuDepartment of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai, China.ORCID https://orcid.org/0009-0002-5492-9096
Qi JiaDepartment of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Rongrong ZhuDepartment of Orthopedics, School of Life Sciences and Technology, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Tongji Hospital Affiliated to Tongji University, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-3955-5965
Yong HuDepartment of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0003-1425-6093

Funding

Fundamental Research Funds for the Central UniversitiesInterdisciplinary Project in "Medicine + X" of Tongji UniversityNational Natural Science Foundation of China 52373154Shanghai Rising-Star Program 2023QA1411700
6 · The paper itself

Abstract

Mesenchymal stem cell-derived exosomes (MSC-Exo) containing various paracrine mediators have recently been recognized to promote functional recovery of spinal cord injury (SCI). However, their biomedical applications are hindered by limited possibilities for specific integration within the delivery systems. In this study, inspired by antibody-antigen binding, we present an unprecedented assembly strategy that leverages immunoaffinity-mimetic interactions of peptide-aptamer (Peptide-Apt

Indexed as

Aptamers, PeptideExosomesMesenchymal Stem CellsSpinal Cord InjuriesAnimalsHumansMiceNeural Stem CellsAptamers, Peptidemesenchymal stem cell‐derived exosomesmicrogelneuroregenerationpeptide‐aptamer conjugatesspinal cord injury

Identifiers

PMID41514481
PMCPMC13042431

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.