Evidence map›Paper›PMID 41514449›Full record

ArticleJournal of ovarian research2026

Integrative multi-omics analysis reveals IFIT3⁺ macrophage-associated ISG20 as a prognostic biomarker and elucidates underlying tumor-suppressive mechanisms in ovarian cancer.

Xiushen Li, Wenhao Wu, Sailing Lin, Xiangyu Yang, Huimin Wang, Xiaoyong Chen, Liqin Bao, Qiongfang Fang, Qi Zhang, Jingxin Ma and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xiushen Li *Department of Traditional Chinese Medicine, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Jiangxi, Nanchang, China.
Wenhao Wu *School of pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, 518055, China.
Sailing Lin *Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.
Xiangyu YangDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, Yuzhong District, China.
Huimin WangDepartment of Traditional Chinese Medicine, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Jiangxi, Nanchang, China.
Xiaoyong ChenDepartment of Traditional Chinese Medicine, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Jiangxi, Nanchang, China.
Liqin BaoSchool of Clinical Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China.
Qiongfang FangShenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.
Qi ZhangShenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.
Jingxin MaShenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.
Lijun FanShenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.
Guli ZhuShenzhen University General Hospital Department of Gynecology and Obstetrics, Shenzhen, China.
Ruiqi WangShenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China.
Xiran WangDepartment of Bioinformatics, School of Health Care, Changchun Vocational College of Health, Changchun, China.
Zhaorui ChengDepartment of Emergency, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, 518060, China. czr168756179@163.com.
Weizheng LiangHebei Key Laboratory of Systems Biology and Gene Regulation, Central Laboratory, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, 075000, China. jmbb1203@126.com.
Xueqing WuShenzhen University General Hospital Department of Gynecology and Obstetrics, Shenzhen, China. wuxueqing0307@163.com.

Funding

Science and Technology Program of Jiangxi Provincial Administration of Traditional Chinese Medicine 2024A0192Shenzhen Pea-cock Program-Project Development Fund 20210407618BShenzhen Science and Technology Innovation Committee JCYJ20210324100004013The Key Programs of Basic and Applied Basic Research Fund of Guangdong Province 2022B1515120063
6 · The paper itself

Abstract

Ovarian cancer (OC) remains the most lethal gynecologic malignancy, with the regulatory role of innate immunity in its progression and treatment poorly understood. This study provides a thorough characterization of OC immune microenvironment by combining multi-omics data. Our findings show innate immune signals in myeloid cells are central to communication within tumor microenvironment. Analysis of innate immune scores revealed IFIT3

Indexed as

Biomarkers, TumorExonucleasesMacrophagesOvarian NeoplasmsFemaleGene Expression Regulation, NeoplasticHumansImmunity, InnateIntracellular Signaling Peptides and ProteinsMultiomicsPrognosisRNA-Binding ProteinsTumor MicroenvironmentBiomarkers, TumorExonucleasesIFIT3 protein, humanIntracellular Signaling Peptides and ProteinsRNA-Binding ProteinsImmunotherapyInnate immunityMacrophageMulti-OmicsOvarian cancerTumor microenvironment

Identifiers

PMID41514449
PMCPMC12903577

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.