Evidence map›Paper›PMID 41514422›Full record

ReviewEuropean journal of medical research2026

Advancements in unilateral biportal endoscopic lumbar interbody fusion: a narrative review.

Penghui Lv, Lu Li, Sichao Cheng, Jincheng Bai, Jianjun Chang

Abstract readReview
In one paragraph

Review in European journal of medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Penghui LvThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Lu LiThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Sichao ChengThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Jincheng BaiThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Jianjun ChangThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China. changjianjun@sxbqeh.com.cn.

Funding

Natural Science Foundation of Shanxi Province 202403021221251
6 · The paper itself

Abstract

introductionLumbar fusion remains a cornerstone for managing degenerative lumbar disorders. Recently, Unilateral Biportal Endoscopic Lumbar Interbody Fusion (ULIF) has emerged as a key minimally invasive technique with promising clinical outcomes. This narrative review analyzes current applications, technical advancements, and the existing evidence base for ULIF. It also highlights the challenges, controversies, and research gaps that may affect its widespread adoption, offering insights to guide future clinical practice.

methodsA structured literature search of the PubMed, Web of Science, Embase, and Cochrane Library databases was conducted for relevant articles published through August 2025. Search terms included "unilateral biportal endoscopic," "UBE," "biportal endoscopic spine surgery," "lumbar interbody fusion," "ULIF," and "BE-TLIF." This review critically synthesizes findings from clinical studies, technical reports, and systematic reviews focusing on surgical techniques, clinical efficacy, fusion outcomes, and complications associated with ULIF.

resultsULIF is increasingly utilized for a wide spectrum of lumbar degenerative diseases. Comparative studies indicate that while ULIF yields comparable long-term fusion rates and clinical improvements to minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF), it offers distinct advantages, such as reduced intraoperative blood loss and shorter hospital stays. However, these benefits are often offset by longer operative times, particularly during the initial learning curve. Technical innovations, including novel cage designs and navigation systems, aim to enhance fusion and restore sagittal alignment. Despite its potential, the technique's adoption is challenged by this steep learning curve and a distinct complication profile, including concerns regarding dural tears, epidural hematomas, and nerve root injuries. Questions also remain regarding its cost-effectiveness and its ability to achieve superior radiological outcomes.

conclusionsULIF represents a safe and effective minimally invasive alternative for treating various lumbar spine disorders. However, its widespread adoption is constrained by its technical demands, a specific complication profile, and unresolved questions regarding its cost-effectiveness and long-term radiological benefits. Future high-quality research, particularly multicenter Randomized Controlled Trials (RCTs), is necessary to definitively establish its long-term efficacy, standardize surgical techniques, and optimize patient safety.

Indexed as

Lumbar degenerative diseaseLumbar interbody fusionMinimally invasive spine surgerySpinal endoscopyUnilateral biportal endoscopic technique

Identifiers

PMID41514422
PMCPMC12882136

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.