Evidence map›Paper›PMID 41514411›Full record

Trial reportBMC oral health2026

Clinical and radiographic evaluation of autologous albumin-rich platelet-rich fibrin membrane versus synthetic collagen membrane for immediate dental implant placement in the maxillary esthetic zone: a preliminary randomized clinical trial.

Hamza Alsabahi, Bassant Mowafey, Islam Kandil, Nesma Elgohary, Jilan Youssef

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06643468 (Evaluation of the Effectiveness of ALB-PRF With Two Types of Bone Grafts With Putty Form in the Treatment of Peri-Implant Bony Defects Around Immediate Dental Implants in the Maxillary Aesthetic Zone.), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06643468 naenrolling by invitationnot on this map

Evaluation of the Effectiveness of ALB-PRF With Two Types of Bone Grafts With Putty Form in the Treatment of Peri-Implant Bony Defects Around Immediate Dental Implants in the Maxillary Aesthetic Zone.

TypeinterventionalSponsorMansoura UniversityRan2024 to 2025Enrolled60ConditionsDental Implants, Immediate Implant Soft Tissue Healing, Immediate Implant With Bone GraftArmsparticipants will receive immediate implant with nano-crystalline putty hydroxyapatite as bone graft and collagen membrane., participants will receive immediate implant with nano-crystalline putty hydroxyapatite as bone graft and ALB- PRF as membrane., participants will receive immediate implant with beta-tricalcium phosphate + calcium sulphate bone graft and collagen membrane., participants will receive immediate implant with beta-tricalcium phosphate + calcium sulphate bone graft and ALB-PRF membrane.
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hamza AlsabahiDepartment of Oral Medicine and Periodontology, Faculty of Dentistry Ibb University, Ibb, Yemen. hamzadent4@gmail.com.ORCID http://orcid.org/0000-0002-5690-9462
Bassant MowafeyDepartment of Oral Medicine, Periodontology, Diagnosis, and Oral Radiology, Faculty of Dentistry, Mansoura University, Mansoura, Aldakahlia, Egypt.
Islam KandilDepartment of Oral Medicine, Periodontology, Diagnosis, and Oral Radiology, Faculty of Dentistry, Mansoura University, Mansoura, Aldakahlia, Egypt.
Nesma ElgoharyDepartment of Fixed Prosthodontics, Faculty of Dentistry, Mansoura University, Mansoura, Aldakahlia, Egypt.
Jilan YoussefDepartment of Oral Medicine, Periodontology, Diagnosis, and Oral Radiology, Faculty of Dentistry, Mansoura University, Mansoura, Aldakahlia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong-term aesthetic stability following immediate implant placement depends on achieving predictable bone regeneration within the peri-implant “jumping gap” and existing labial bone defects. Despite using a beta-tricalcium phosphate/calcium sulfate putty bone graft (β-TCP + CS), regenerative membranes are essential adjuncts to ensure superior healing. Therefore, this preliminary study aimed to determine whether autologous Albumin-Platelet-Rich Fibrin (Alb-PRF) provides superior aesthetic and osseous outcomes compared with the standard synthetic collagen membrane. PATIENTS AND

methodsThis single-blind, preliminary randomized clinical trial involved 20 participants with a non-restorable maxillary aesthetic tooth and a labial bone defect who received immediate implants. Participants were allocated into two groups (n=10 each): Group I received a β-TCP + CS putty combined with a synthetic collagen membrane, while Group II received the same bone graft combined with an Alb-PRF membrane placed in the labial jumping gap. Primary outcome variables, including marginal bone loss (MBL) and labial bone thickness (LBT), were assessed via CBCT at baseline, 6 months, and 12 months. Secondary outcomes included the Pink Esthetic Score (PES) and clinical parameters (Plaque Index, Bleeding on Probing, and Peri-implant Probing Depth), which were measured at baseline, 4, 6, and 12 months post-surgery.

resultsClinical parameters showed no significant inter-group differences. However, Group II demonstrated significantly higher PES scores at 4 months (p=0.027) and 12 months (p=0.018). While Group I exhibited significantly better preservation of LBT at 6 months (p=0.005) and 12 months (p=0.001), Group II showed significantly less MBL at 6 months (P ≤ 0.001) and 12 months (p=0.023).

conclusionBoth membranes effectively treat peri-implant defects. While the collagen membrane better preserves labial bone thickness, Alb-PRF yields superior aesthetic scores and reduces marginal bone loss.

trial registrationThis preliminary randomized clinical trial was registered on ClinicalTrials.gov and approved on 15/10/2024 with trial number (NCT06643468).

Indexed as

AlbuminsCollagenEsthetics, DentalImmediate Dental Implant LoadingMaxillaMembranes, ArtificialPlatelet-Rich FibrinAdultBone RegenerationBone TransplantationCalcium PhosphatesFemaleHumansMaleMiddle AgedSingle-Blind MethodAlbuminsbeta-tricalcium phosphateCalcium PhosphatesCollagenMembranes, ArtificialAlbumin-Platelet-Rich fibrinAlloplastic bone grafting materialBone substitutesCalcium phosphatesCalcium sulfateCollagen membraneDental implantation

Identifiers

PMID41514411
PMCPMC12903329

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.