SynthesisJournal of health, population, and nutrition2026
The effect of Quercetin supplementation on hyperuricemia-related biochemical and renal outcomes in animal models: a systematic review and meta-analysis.
Synthesis in Journal of health, population, and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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3 authors.
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Abstract
backgroundQuercetin, has been proposed as a supplement to improve uric acid -related indices. However, finding supporting evidence remains inconsistent. This meta-analysis aimed to assess the effects of quercetin supplementation on lipid profile, renal function indices, oxidative stress, and inflammatory biomarkers.
methodsA systematic review of PubMed, Web of Science, Embase, China Knowledge Network, China Science and Technology Journal Database, and Wanfang Data Knowledge Service Platform from inception to August 2024 were searched. Data were pooled using a random-effects model.
resultsSeventeen case studies were included. Quercetin supplementation significantly reduced serum uric acid (UA), creatinine (Cr), fractional excretion of uric acid (FEur), and blood urea nitrogen (BUN) levels, and improved oxidative stress and inflammatory markers, including malondialdehyde (MDA), superoxide dismutase (SOD), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-a) (p < 0.05). Improvements were also observed in lipid parameters such as triglycerides (TG) and very-low density lipoprotein (VLDL) (p < 0.05). Subgroup analyses indicated that dose and intervention duration influenced outcomes, but the direction and magnitude varied by specific biomarker. However, quercetin supplementation did not have significant effect on urinary UA, urinary Cr, and low density lipoprotein-cholesterol (LDL-C) (p > 0.05).
conclusionsOur findings suggest that quercetin has the potential to improve key biochemical markers, including SUA, VLDL, TNF-α, TG, SOD, Cr, BUN, MDA, IL-6, and FEur, in animal models of hyperuricemia. However, due to high heterogeneity across studies and varying risk of bias, these results should be interpreted cautiously.
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