ReviewJournal of anesthesia, analgesia and critical care2026
Dead space in critical care: a practical approach with clinical scenarios.
Review in Journal of anesthesia, analgesia and critical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Carbon dioxide (CO₂) is a byproduct of cellular metabolism, with the human body storing approximately 120 liters in various chemical forms across different compartments. Through gas exchange and tidal ventilation, arterial CO₂ and blood pH are tightly regulated within the narrow ranges required for cellular function. Not all tidal ventilation, however, contributes to CO₂ elimination: the portion of each breath that does not participate in gas exchange is defined as dead space. First described in 1891 by Christian Bohr in his seminal work "Über die Lungenatmung", the concept gained practical applicability in 1938 when Enghoff proposed replacing the unmeasurable alveolar partial pressure CO₂ (PACO₂) with the arterial partial pressure of CO
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