Evidence map›Paper›PMID 41514271›Full record

ArticleBMC oral health2026

Potassium in dental calculus as an indicator of diabetes.

Z Szepesi, R Kállai, A Csík, I Varga, K Tőkési

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Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Z SzepesiDepartment of Periodontology, Faculty of Dentistry - University of Debrecen, Debrecen, EU, Hungary.
R KállaiDepartment of Periodontology, Faculty of Dentistry - University of Debrecen, Debrecen, EU, Hungary.
A CsíkHUN-REN Institute for Nuclear Research, (ATOMKI), Debrecen, EU, Hungary.
I VargaDepartment of Periodontology, Faculty of Dentistry - University of Debrecen, Debrecen, EU, Hungary. varga.istvan@dental.unideb.hu.
K TőkésiHUN-REN Institute for Nuclear Research, (ATOMKI), Debrecen, EU, Hungary. tokesi@atomki.hu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetes Mellitus (DM) is a chronic metabolic disorder that has been linked to an increased risk of periodontal disease. Among the oral manifestations associated with DM, periodontal disease has been the most extensively studied. Dental calculus, which forms when dental plaque mineralizes over time, is known to trap biological substances and may preserve biochemical markers indicative of systemic health. Therefore, it could provide valuable information about patients' overall health. In this study, we analyzed the elemental composition of dental calculus in diabetic and non-diabetic (control) patients using scanning electron microscopy (SEM) combined with energy dispersive X-ray spectroscopy (EDX), with a specific focus on potassium (K) content. PATIENTS AND

methodsWe analyzed 57 dental calculus samples, including 17 from individuals diagnosed with type 2 diabetes and 40 from non-diabetic controls. The elemental composition was assessed using scanning electron microscopy paired with energy-dispersive X-ray spectroscopy (SEM-EDX), targeting standardized 100 × 100 μm regions. Potassium content, along with other elemental data, was reported in both mass and atomic percentages.

resultsThe results showed elevated potassium levels in diabetic patients compared to controls, with the difference reaching the treshold of statistical significance (0.484 ± 0.710 wt.% versus 0.186 ± 0.320 wt.%). A similar trend was observed in atomic percentage values (0.249 ± 0.387 versus 0.092 ± 0.174; p = 0.0555). Notably, potassium was present in 100% of the diabetic samples. Carbon and oxygen were the predominant elements in both groups, with the diabetic group exhibiting a slight increase in oxygen and lower levels of calcium and phosphorus.

conclusionThese findings suggest that potassium concentration in dental calculus could serve as a potential biomarker for diabetes. They also highlight the feasibility of incorporating dental calculus analysis after routine dental treatments- which involve the removal of calculus-for early diabetes detection. This approach provides a cost-effective and painless alternative to traditional diagnostic methods. However, we note that while the data are still preliminary, the results indicate a potential biochemical link that warrants further exploration in larger, well-controlled studies.

Indexed as

Dental CalculusDiabetes Mellitus, Type 2PotassiumBiomarkersCase-Control StudiesFemaleHumansMaleMicroscopy, Electron, ScanningMiddle AgedSpectrometry, X-Ray EmissionBiomarkersPotassiumBiomarkerDental calculusDiabetes mellitusPotassiumSEM-EDX

Identifiers

PMID41514271
PMCPMC12903439

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.