ArticleBMC cardiovascular disorders2026
Impact of left atrial appendage closure with or without radiofrequency ablation on cardiac remodeling in atrial fibrillation patients.
Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Advances of Fully Biodegradable Poly-p-Dioxanone and Polylactic Acid-Based Polymers as Left Atrial Appendage Closure Devices.Macromolecular bioscience · 2026Review
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Authors and funding
8 authors.
Funding
Abstract
objectiveThis study aimed to explore the effects of the left atrial appendage closure (LAAC) procedure or LAAC combined with Radiofrequency Catheter Ablation (RFCA) on the cardiac structure and function in patients with atrial fibrillation (AF).
methodsThis retrospective cohort study included 130 patients with AF, of whom 83 underwent simple LAAC and 47 underwent LAAC combined with RFCA. Echocardiographic parameters, including left ventricular end-diastolic diameter (LVEDs), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF), and fractional shortening (FS), were assessed at baseline and at 3, 6, and 12 months postoperatively. Analyses were performed for the overall cohort and stratified by the presence of chronic heart failure (CHF).
resultsIn the overall cohort, postoperative echocardiographic assessments demonstrated time-dependent changes in cardiac systolic function and structure. Changes in systolic function were predominantly observed during the early follow-up period (3-6 months), whereas structural parameters, particularly ventricular dimensions and volumes, exhibited more sustained changes throughout follow-up. When treatment strategies were compared, patients undergoing LAAC combined with RFCA showed more pronounced postoperative changes in indices of systolic function and ventricular volumes at multiple follow-up time points compared with those treated with simple LAAC. In subgroup analyses, remodeling trajectories differed according to heart failure status. Patients with CHF generally exhibited attenuated functional changes over time, whereas patients without CHF demonstrated more apparent early systolic functional changes, while structural parameters showed relatively consistent trends across subgroups.
conclusionIn this retrospective cohort, LAAC combined with RFCA was associated with more favorable cardiac remodeling patterns than simple LAAC. These differences likely reflect rhythm restoration achieved through RFCA rather than a direct effect of LAAC itself.
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