ReviewMolecular neurobiology2026
The Emerging Role of L-Arginine and Creatine Supplementation Combined with Exercise on Hippocampal Neurogenesis, Spatial Learning, and Cognitive Flexibility in Aging and Neurodegenerative Diseases.
Review in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Multifaceted roles of arginine in cellular function, signaling, and disease.Frontiers in chemistry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hippocampal neurogenesis is a pivotal process for cognitive adaptability, memory consolidation, and the regulation of emotions, all of which exhibit a decline as individual's age and contribute to the onset of neurodegenerative and mood disorders. The disruption of neurogenesis adversely affects these cognitive functions, establishing a connection between memory impairments and emotional disturbances, including anxiety and depression. Recent empirical studies underscore the promising effects of creatine and L-arginine supplementation, in conjunction with physical exercise, in enhancing hippocampal neuroplasticity and fostering neurogenesis. Creatine, recognized for its critical involvement in energy metabolism, plays a supportive role in neuronal integrity and cognitive performance, while L-arginine enhances nitric oxide-mediated neurovascular coupling and trophic support, and physical exercise activates neurogenic pathways and elevates mood. This review delineates the intricate interactions among hippocampal neurogenesis, cognitive flexibility, memory, and emotional functionality in the context of aging-related pathologies. This discourse examines the potential synergistic effects of creatine, L-arginine, and physical exercise in combating age-associated cognitive and emotional deterioration by influencing neurogenic and metabolic processes within the hippocampal region. While previous literature has scrutinized these interventions in isolation, no research to date has amalgamated their collective mechanistic impacts on hippocampal neurogenesis. This review distinctly integrates bioenergetic and neurotrophic pathways to furnish a coherent viewpoint on the interplay between exercise and creatine in the context of cognitive aging. Grasping these interrelations yields novel insights into therapeutic modalities designed to enhance cerebral resilience and psychological well-being among the elderly population. This comprehensive framework presents promising opportunities for the prevention and management of cognitive deficits and mood disturbances via lifestyle modifications and nutritional strategies.
Indexed as
Identifiers
41514140What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.