Evidence map›Paper›PMID 41514111›Full record

ArticleBulletin of experimental biology and medicine2025

A Rational Approach to Developing a Phage Biopreparation: Boosting Lytic Efficiency and Countering Resistance in Pathogenic Escherichia coli.

E R Zulkarneev, N V Pimenov, A S Tishchenko, T A Kapustina, S V Pozyabin

Abstract read
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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

E R ZulkarneevMoscow State Academy of Veterinary Medicine and Biotechnology Named after K. I. Skryabin, Moscow, Russia. elzz@mail.ru.
N V PimenovMoscow State Academy of Veterinary Medicine and Biotechnology Named after K. I. Skryabin, Moscow, Russia.
A S TishchenkoKuban State Agrarian University Named after I. T. Trubilin, Krasnodar, Russia.
T A KapustinaMoscow State Academy of Veterinary Medicine and Biotechnology Named after K. I. Skryabin, Moscow, Russia.
S V PozyabinMoscow State Academy of Veterinary Medicine and Biotechnology Named after K. I. Skryabin, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antimicrobial activity of Escherichia phage Ec1-7 and Escherichia phage Ec2-7 was evaluated both separately and in a phage cocktail. The combination of phages significantly extended the spectrum of lytic activity and effectively inhibited the growth of bacteria, including strains with emerging resistance. The phage cocktail exhibited higher efficacy (3.6-4.8 lg(CFU/ml)) in comparison with monophages (1.3-2.8 lg(CFU/ml)) during a 6-h incubation period: it prevented secondary bacterial growth and reduced the likelihood of resistance development. Our findings corroborate the potential of phage cocktails in combating antibiotic-resistant strains.

Indexed as

BacteriophagesColiphagesEscherichia coliPhage TherapyAnti-Bacterial AgentsDrug Resistance, BacterialEscherichia coli InfectionsMicrobial Sensitivity TestsAnti-Bacterial Agentsantibiotic resistancebacteriophageE. coli (STEC, APEC, UPEC)phage therapy

Identifiers

PMID41514111

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.