ArticleClinical oral investigations2026
Orthonasal bioactive volatiles and their effects on salivation: a pilot study.
Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Salivary responses to chewing mastic resin and parafilm and inhalation of mastic- and α-pinene-derived volatiles in healthy young adults.Frontiers in dental medicine · 2026Article
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4 authors.
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Abstract
objectivesPrevious findings showed that nasal exposure to mastic resin volatiles stimulated salivary flow both in healthy volunteers and dry-mouth patients. This prompted the search for new volatile sialagogic compounds as well as other, more standardized delivery methods. Therefore, this study aimed to assess the sialagogic effects of α-pinene, basil, eugenol, and guaiacol volatiles using nasal inhalers. MATERIALS AND
methodsα-Pinene, basil, eugenol, and guaiacol volatiles were administered using nasal inhalers to act as an olfactory stimulus in healthy individuals (n = 12). Salivary flow, spinnbarkeit, and subjective mouthfeel were assessed before and after the use of the compounds. Furthermore, the possible effect of placebo nasal inhalers on salivary flow was also assessed.
resultsStimulation with basil and guaiacol applied with nasal inhalers resulted in an increase in salivary flow (p ≤ 0.01). Furthermore, basil improved the feeling of moistness in the oral cavity (p < 0.05). The use of nasal inhalers did not reveal any placebo effect in healthy individuals.
conclusionsThese findings demonstrate that nasal inhalation of basil volatiles can effectively enhance salivary secretion and improve the sensation of oral moisture. This suggests basil in particular being a promising candidate for developing new topical treatment for dry mouth. Further studies with larger cohorts and clinical trials in dry-mouth patients are necessary to confirm and extend these results.
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