ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long-Term Fine Particulate Matter Exposure.
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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
22 authors.
Chenxu GeKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing University, Chongqing, P. R. China.
Jiamao LinTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Changsheng YangDepartment of Orthopedic Oncology Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, P. R. China.
Chuanwang MiaoDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, P. R. China.
Fengxiang LiDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, P. R. China.
Shuqiang ZhaoDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, P. R. China.
Lei ZouDepartment of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, P. R. China.
Xuedong TengUltrasound Department, Yantai Qishan Hospital, Yantai, P. R. China.
Lina LiuDepartment of General Surgery, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, P. R. China.
Tingguang LiTraditional Chinese Medicine Discipline, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, P. R. China.
Yan SunKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing University, Chongqing, P. R. China.
Qiang LiChongqing Key Laboratory of Functional Substances from Distinctive Medicinal Plants in the Three Gorges Reservoir Area, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, P. R. China.
Deshuai LouChongqing Key Laboratory of Functional Substances from Distinctive Medicinal Plants in the Three Gorges Reservoir Area, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, P. R. China.
Linfeng HuChongqing Key Laboratory of Functional Substances from Distinctive Medicinal Plants in the Three Gorges Reservoir Area, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, P. R. China.
Xi LiuChongqing Key Laboratory of Functional Substances from Distinctive Medicinal Plants in the Three Gorges Reservoir Area, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, P. R. China.
Gang KuangChongqing Key Laboratory of Functional Substances from Distinctive Medicinal Plants in the Three Gorges Reservoir Area, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, P. R. China.
Jing LuoChongqing Key Laboratory of Functional Substances from Distinctive Medicinal Plants in the Three Gorges Reservoir Area, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, P. R. China.
Minxuan XuKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing University, Chongqing, P. R. China.ORCID https://orcid.org/0000-0002-0742-4717
Minghui ChangTumor Research and Therapy Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, P. R. China.ORCID https://orcid.org/0000-0002-4498-6604
Jun TanChongqing Key Laboratory of Functional Substances from Distinctive Medicinal Plants in the Three Gorges Reservoir Area, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, P. R. China.
Yanrong RenChongqing Key Laboratory of Functional Substances from Distinctive Medicinal Plants in the Three Gorges Reservoir Area, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, P. R. China.
Bochu WangKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing University, Chongqing, P. R. China.
Funding
Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education Open Projects Fund xnykdxcxzx-2024-04Basic Medicine Research Innovation Center for Cardiometabolic Diseases, Ministry of Education Open Projects Fund xnykdxcxzx-2024-15Children's Research Institute of National Center for Schooling Development Programme and Chongqing University of Education CSDP19FSO1108Chongqing Natural Science Foundation Innovation Development Joint Fund CSTB2022NSCQ-LZX0053Chongqing Professional Talents Plan for Innovation and Entrepreneurship Demonstration Team CQCY201903258Chongqing Research Program of Basic Research and Frontier Technology 2022NSCQ-MSX5364National Natural Science Foundation of China 32471324National Natural Science Foundation of China 82200652National Natural Science Foundation of China 82403143The Scientific and Technological Research Program of Chongqing Municipal Education Commission of China KJZD-M202201602
Abstract
Particulate matter ≤2.5 µm (PM
Indexed as
HypothalamusMetabolic DiseasesNeuronsParticulate MatterPro-OpiomelanocortinTripartite Motif ProteinsUbiquitin-Protein LigasesAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutOxidative StressParticulate MatterPro-OpiomelanocortinTripartite Motif ProteinsUbiquitin-Protein Ligaseshypothalamic POMC+ neuronsmetabolic disorderNrf2PM2.5TRIM31
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.