SynthesisOrthopadie (Heidelberg, Germany)2026
No significant short-term advantages of corticosteroids-augmented intra-articular injections of hyaluronic acid for knee osteoarthritis : A meta-analysis.
Synthesis in Orthopadie (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
introductionThe present meta-analysis investigated whether augmenting hyaluronic acid (HA) with corticosteroids (CCs) is more effective than HA in isolation in patients with knee osteoarthritis (OA). The outcomes of interest were the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores.
methodsThis study was conducted according to the 2020 PRISMA statement. In September 2025 the following databases were accessed: PubMed, Web of Science, Google Scholar and Embase. All head-to-head randomized controlled trials (RCTs) comparing intra-articular injections of HA in isolation versus HA augmented with CCs were accessed.
resultsData from 216 patients were collected and 74% (162 of 216) of the patients were women. The mean patient age was 57.7 ± 4.4 years and the mean body mass index (BMI) was 28.2 ± 3.0 kg/m
conclusionThe current level I of evidence suggests that intra-articular HA injections augmented with CCs do not appear to provide clinically relevant advantages in WOMAC outcomes within 3-6 months of follow-up.
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