Evidence map›Paper›PMID 41513980›Full record

ArticlePediatric research2026

Hydrocortisone administration in preterm infants is not associated with adverse cardiovascular outcomes in childhood.

Cherine Benzouid, Plamen Bokov, Pierre Coste, Sehomi Azonaha, Kadiatou Diallo, Sophie Guilmin-Crépon, Olivier Baud, Valérie Biran, Christophe Delclaux

Registry-linked trialAbstract read
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In one paragraph

Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05451264 (Study of the Effect of Hydrocortisone Administered for the Prevention of Pulmonary Bronchodysplasia), which is not on this map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05451264 nacompletednot on this map

Study of the Effect of Hydrocortisone Administered for the Prevention of Pulmonary Bronchodysplasia (PREMILOC Trial) on the Determinants of Systemic Blood Pressure in Children

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2023 to 2024Enrolled52ConditionsInfant, Premature, DiseasesArmsblood pressure measurement
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cherine BenzouidDepartment of Physiology, AP-HP, Robert Debré Hospital, Paris, France.
Plamen BokovParis Cité University, AP-HP, Robert Debré Hospital, Department of Physiology, INSERM NeuroDiderot, Paris, France.
Pierre CosteClinical Research Unit, AP-HP, Robert Debré Hospital, Paris, France.
Sehomi AzonahaClinical Research Unit, AP-HP, Robert Debré Hospital, Paris, France.
Kadiatou DialloClinical Research Unit, AP-HP, Robert Debré Hospital, Paris, France.
Sophie Guilmin-CréponClinical Research Unit, AP-HP, Robert Debré Hospital, Paris, France.
Olivier BaudDepartment of Neonatal Medicine, Paris Cité University, AP-HP, Cochin-Port Royal Hospital, Paris, France.
Valérie BiranDepartment of Neonatal Medicine, Paris Cité University, AP-HP, Robert Debré Hospital, Paris, France.
Christophe DelclauxParis Cité University, AP-HP, Robert Debré Hospital, Department of Physiology, INSERM NeuroDiderot, Paris, France. christophe.delclaux@aphp.fr.ORCID http://orcid.org/0000-0003-2786-0812

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo assess whether administering hydrocortisone in the perinatal period is associated with subsequent adverse cardiovascular outcomes.

methodsThe children/adolescents enrolled in the PREMILOC trial underwent resting blood pressure (BP) measurement, tonometry evaluation (pulse wave velocity (PWV), aortic systolic BP), continuous BP and ECG measurements (supine and standing), and ambulatory BP monitoring. Heart rate variability (HRV) indices, baroreflex sensitivity (BRS), and orthostatic systolic BP (SBP) response were calculated.

resultsFifty-two subjects (median [25th; 75th percentile] birth weight: 892 g [750; 982]; gestational age: 26

conclusionEarly hydrocortisone administration after extremely preterm birth in a randomized trial is not associated with detrimental cardiovascular indices in children/adolescents, while overweight/obesity is already associated with cardiovascular morbidity. The study has been registered, ClinicalTrials.gov ID NCT05451264: https://clinicaltrials.gov/study/NCT05451264?cond=NCT05451264&rank=1 . IMPACT: A meta-analysis on the effects of early postnatal administration of corticosteroids concluded that the hypertensive risk was increased in infants, but that long-term studies should be carried out. We show that early hydrocortisone administration after extremely preterm birth in a randomized trial is not associated with detrimental cardiovascular indices in children/adolescents, at least in one center of the trial Thus, our study suggests that early markers of the risk of hypertension are not altered by hydrocortisone.

Identifiers

PMID41513980

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