Evidence map›Paper›PMID 41513918›Full record

ArticleScientific reports2026

Chemical and biological profiling of bioactive metabolites from the invertebrate-pathogenic fungus Gibellula scorpioides BCC 39989.

Ubon Rerk-Am, Boonchoy Soontornworajit, Yuthana Tantirungrotechai, Pichayanoot Rotkrua, Praphakorn Kaemchantuek, Sarunya Laovitthayanggoon, Pattarawadee Kengkwasingh, Artit Khonsanit, Donnaya Thanakitpipattana, Wilawan Kuephadungphan and 2 more

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Ubon Rerk-AmDepartment of Chemistry, Faculty of Science and Technology, Thammasat University, Pathum Thani, 12120, Thailand.
Boonchoy SoontornworajitDepartment of Chemistry, Faculty of Science and Technology, Thammasat University, Pathum Thani, 12120, Thailand.
Yuthana TantirungrotechaiDepartment of Chemistry, Faculty of Science and Technology, Thammasat University, Pathum Thani, 12120, Thailand.
Pichayanoot RotkruaThammasat University Research Unit in Innovation of Molecular Hybrid for Biomedical Application, Pathum Thani, 12120, Thailand.
Praphakorn KaemchantuekExpert Centre of Innovative Herbal Products, Thailand Institute of Scientific and Technological Research, Pathum Thani, 12120, Thailand.
Sarunya LaovitthayanggoonExpert Centre of Innovative Herbal Products, Thailand Institute of Scientific and Technological Research, Pathum Thani, 12120, Thailand.
Pattarawadee KengkwasinghExpert Centre of Innovative Herbal Products, Thailand Institute of Scientific and Technological Research, Pathum Thani, 12120, Thailand.
Artit KhonsanitPlant Microbe Interaction Research Team, BIOTEC, National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Khlong Luang, Pathum Thani, 12120, Thailand.
Donnaya ThanakitpipattanaPlant Microbe Interaction Research Team, BIOTEC, National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Khlong Luang, Pathum Thani, 12120, Thailand.
Wilawan KuephadungphanPlant Microbe Interaction Research Team, BIOTEC, National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Khlong Luang, Pathum Thani, 12120, Thailand.
Janet Jennifer Luangsa-ArdPlant Microbe Interaction Research Team, BIOTEC, National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Khlong Luang, Pathum Thani, 12120, Thailand. jajen@biotec.or.th.
Jiraporn ArunpanichlertDepartment of Chemistry, Faculty of Science and Technology, Thammasat University, Pathum Thani, 12120, Thailand. jira_550@tu.ac.th.

Funding

National Science and Technology Development Agency (NSTDA) Grant no. P21-50844Southeast Asia-Europe Joint Funding Scheme SEA-Europe Grant No. JFS20ST-127, Acronym: AntiviralfunThailand Science Research and Innovation Fundamental Fund Contract No. TUFF 20/2565Thammasat University Research Fund Contract No. TUFT-FF 16/2565
6 · The paper itself

Abstract

Gibellula scorpioides BCC 39989 is one of the species of spider-parasitic Gibellula (Hypocreales, Cordycipitaceae) discovered in Thailand. Investigation of the invertebrate-pathogenic fungus G. scorpioides BCC 39989 led to the isolation of eight known compounds (1-8). Their chemical structures were determined by employing extensive spectroscopic analysis. Among them, ergosterol peroxide (1) and methyl o-hydroxycinnamate (2) exhibited significant biological activities. Both compounds notably suppressed LPS-induced nitric oxide production and reduced IL-6 and TNF-α secretion in RAW264.7 macrophages. In addition, compounds 1, 2, and oleic acid (7) significantly inhibited lipid accumulation and reduced intracellular triglyceride content in 3T3-L1 adipocytes in a dose-dependent manner. Compound 1 also displayed potent antiproliferative activity against human colorectal adenocarcinoma (SW480) cells, with an IC

Indexed as

ErgosterolHypocreales3T3-L1 CellsAnimalsAnti-Inflammatory AgentsCell Line, TumorCell ProliferationHumansMacrophagesMiceNitric OxideRAW 264.7 CellsTumor Necrosis Factor-alphaAnti-Inflammatory AgentsErgosterolergosterol-5,8-peroxideNitric OxideTumor Necrosis Factor-alphaAnti-adipogenic activityAnti-inflammatory activityAntiproliferative activityGenotoxicityGibellula scorpioidesInvertebrate-pathogenic fungus

Identifiers

PMID41513918
PMCPMC12873349

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.