ArticleScientific reports2026
GC-MS characterization and in-silico evaluation of TNF-α binding efficacy of leaf extract from Abies spectabilis (D. Don) Spach.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
Abies spectabilis, a medicinal conifer native to the Himalayas, has long been recognized in traditional medicine for its therapeutic properties, particularly in the treatment of inflammatory and respiratory disorders. This study aimed to investigate the phytochemical constituents of its aqueous leaf extract and evaluate the anti-inflammatory potential of its bioactive compounds through in-silico approaches. Qualitative phytochemical analysis confirmed the presence of flavonoids, alkaloids, coumarins, tannins, and naphthoquinones, known for their antioxidant and immunomodulatory properties. Subsequent GC-MS profiling revealed ten major compounds, including Pyrazole[4,5-b]imidazole, siloxanes, and heterocyclic derivatives. The anti-inflammatory potential of the leaf extract was estimated through COX-1 and COX-2 inhibition assays, which yielded IC₅₀ values of 28.757 ± 0.045 µg mL
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