ArticleJournal of molecular histology2026
Estrogen receptor beta activates regenerating family member 1 beta to modulate fibroblast function in pelvic organ prolapse.
Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The pathogenesis of pelvic organ prolapse (POP) is associated with the decline in estrogen levels post-menopause, which ultimately weakens the mechanical properties of pelvic floor connective tissue. Regenerating (REG) family of proteins, particularly REG1B, regulates tissue repair and regeneration through the modulation of cell proliferation and extracellular matrix (ECM) remodeling. In this study, we utilized ovariectomized (OVX) mice, a recognized animal model for human menopause, to elucidate the mechanisms by which REG1B regulates the function of vaginal wall fibroblasts in POP. Expressions of REG1B and fibroblast-to-myofibroblast transition (FMT) markers in vaginal wall tissues from patients with POP and OVX mice were analyzed using immunohistochemistry and Western blot techniques. The effects of REG1B on the proliferation, migration, and invasion of mouse vaginal wall fibroblasts were evaluated using the Cell Counting Kit-8, cell scratch, and transwell invasion assays. REG1B’s impact on fibroblast collagen and ECM metabolism was examined via Western blot. Dual-luciferase reporter and chromatin immunoprecipitation assays validated the transcriptional regulation of REG1B mediated by estrogen receptor beta (ERβ) through direct binding to its promoter region. REG1B was downregulated in the vaginal wall tissues of patients with POP and OVX mice, whereas markers of FMT were upregulated. The knockdown of REG1B suppressed fibroblast proliferation, migration, and invasion, while simultaneously increasing the expression of FMT markers and promoting ECM remodeling. Activation of ERβ enhanced fibroblast proliferation, migration, and invasion by upregulating the expression of REG1B.This study elucidates the mechanism by which ERβ activation promotes fibroblast proliferation, migration, and invasion through REG1B, providing new insights for regenerative medicine approaches in pelvic floor reconstruction. These findings provide a theoretical foundation for understanding the mechanisms of POP and for developing REG1B-targeted preventive and therapeutic strategies.
Indexed as
Identifiers
41513866What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.