Evidence map›Paper›PMID 41513732›Full record

ArticleScientific reports2026

Ultrasound stimulation increases cartilage synthesis and revert dedifferentiation on human chondrocytes.

Sofia Oliveira, Débora Ferreira, Jorge Padrão, Susana O Catarino, Francisca Monteiro, Andrea Zille, Ligia R Rodrigues, Filipe S Silva, Betina B Hinckel, Óscar Carvalho and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sofia OliveiraCMEMS-UMinho, University of Minho, Guimarães, 4800-058, Portugal. sofiaoliveira@dem.uminho.pt.
Débora FerreiraCEB-Centre of Biological Engineering, University of Minho, Campus de Gualtar, Braga, 4710-057, Portugal.
Jorge PadrãoCentre for Textile Science and Technology (2C2T), Department of Textile Engineering, University of Minho, Campus of Azurém, Guimarães, 4800-058, Portugal.
Susana O CatarinoCMEMS-UMinho, University of Minho, Guimarães, 4800-058, Portugal.
Francisca MonteiroCMEMS-UMinho, University of Minho, Guimarães, 4800-058, Portugal.
Andrea ZilleCentre for Textile Science and Technology (2C2T), Department of Textile Engineering, University of Minho, Campus of Azurém, Guimarães, 4800-058, Portugal.
Ligia R RodriguesCEB-Centre of Biological Engineering, University of Minho, Campus de Gualtar, Braga, 4710-057, Portugal.
Filipe S SilvaCMEMS-UMinho, University of Minho, Guimarães, 4800-058, Portugal.
Betina B HinckelDepartment of Orthopaedic Surgery, William Beaumont Hospital, Royal Oak, MI, USA.
Óscar CarvalhoCMEMS-UMinho, University of Minho, Guimarães, 4800-058, Portugal.
Ana LealCMEMS-UMinho, University of Minho, Guimarães, 4800-058, Portugal.

Funding

Fundação para a Ciência e a Tecnologia 2022.01681.CEECIND/CP1718/CT0013Fundação para a Ciência e a Tecnologia PTDC/EME-EME/4520/2021Fundação para a Ciência e a Tecnologia UI/BD/09375/2020Fundação para a Ciência e a Tecnologia UI/BD/150951/2021Fundação para a Ciência e a Tecnologia UID/CTM/00264/2020Fundação para a Ciência e Tecnologia PTDC/EME-EME/1681/2021
6 · The paper itself

Abstract

Therapeutic ultrasound (US) holds promise as a potential therapy to treat articular cartilage; however, optimized and targeted US protocols are lacking. This study aimed at determining an appropriate set of US protocols for stimulating human chondrocyte activity. Human chondrocytes were exposed to various US parameters, including different central frequencies, power densities, operation modes, pulse parameters, and durations, either daily or every other day over a three-day period. Temperature was monitored during stimulation. Protocols that showed the greatest potential for increasing chondrocyte metabolic activity and proliferation were further investigated and extended to a seven-day application. Cartilage matrix synthesis was analyzed by immunocytochemistry, qPCR, and glycosaminoglycans staining. Chondrocytes exposed to 250 mW/cm

Indexed as

Cartilage, ArticularCell DedifferentiationChondrocytesChondrogenesisUltrasonic WavesAggrecansCell ProliferationCells, CulturedCollagen Type IIGlycosaminoglycansHumansAggrecansCollagen Type IIGlycosaminoglycansArticular cartilageChondrocyteDedifferentiationExtracellular matrixTherapeutic ultrasound

Identifiers

PMID41513732
PMCPMC12864824

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.