Evidence map›Paper›PMID 41513658›Full record

ArticleScientific data2026

Matched MRI, Segmentations, and Histopathologic Images of Brain Metastases from Primary Lung Cancer.

Saahil Chadha, Durga V Sritharan, Darin Dolezal, Sampada Chande, Thomas Hager, Khaled Bousabarah, Mariam S Aboian, Veronica Chiang, MingDe Lin, Don X Nguyen and 1 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Saahil ChadhaDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, USA.ORCID http://orcid.org/0009-0002-8519-7895
Durga V SritharanDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, USA.ORCID http://orcid.org/0009-0000-6553-209X
Darin DolezalDepartment of Pathology, Yale School of Medicine, New Haven, USA.
Sampada ChandeDepartment of Pathology, Yale School of Medicine, New Haven, USA.
Thomas HagerDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, USA.
Khaled BousabarahVisage Imaging, GmbH, Berlin, Germany.
Mariam S AboianDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, USA.
Veronica ChiangDepartment of Neurosurgery, Yale School of Medicine, New Haven, USA.
MingDe LinDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA.ORCID http://orcid.org/0000-0001-7641-2595
Don X NguyenDepartment of Pathology, Yale School of Medicine, New Haven, USA.
Sanjay AnejaDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, USA. sanjay.aneja@yale.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain metastases occur in approximately 30-40% of lung cancer patients, and outcomes are heterogeneous, dependent on a combination of clinical, radiologic, pathologic, and molecular characteristics. Though artificial intelligence-based prognostic models show promise, their use is limited by a lack of high-quality training data. Thus, there is a critical need for a large, heterogeneous, annotated, open-access brain metastasis dataset with matched radiologic and histopathologic imaging. We present such a dataset composed of 111 cases of magnetic resonance (MR) and histopathologic imaging from patients with brain metastasis from primary lung cancer. We provide pre-operative T1-weighted contrast-enhanced (T1CE) and fluid-attenuated inversion recovery (FLAIR) MR images with matched whole slide images of formalin-fixed, paraffin-embedded (FFPE) brain metastasis biopsies. The dataset also includes segmentations of contrast enhancement and FLAIR hyperintensity, radiomic features, and clinical information. A Kaplan-Meier analysis validated that the dataset's patients are consistent with prior large retrospective studies of patients with brain metastasis from lung cancer. The provided dataset will facilitate the development of multimodal models for improved management of lung cancer patients.

Indexed as

Brain NeoplasmsLung NeoplasmsMagnetic Resonance ImagingHumans

Identifiers

PMID41513658
PMCPMC12808229

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.