Evidence map›Paper›PMID 41513608›Full record

ArticleTranslational psychiatry2026

Impairment in stimulus-response learning as a cognitive biomarker in a model of synucleinopathy.

Oren Princz-Lebel, Anoosha Attaran, Rodrigo Sandoval Contreras, Vladislav Novikov, Samina Panjwani, Anthony Chu, Cherisse Tan, Claire A Lemieux, Miguel Skirzewski, Meira M F Machado and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Nanoscale CabioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Oren Princz-Lebel *The Graduate Program in Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Anoosha Attaran *Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Rodrigo Sandoval ContrerasRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID http://orcid.org/0009-0000-1167-2513
Vladislav NovikovThe Graduate Program in Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Samina PanjwaniThe Graduate Program in Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Anthony ChuThe Graduate Program in Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID http://orcid.org/0009-0003-9363-698X
Cherisse TanDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0002-3945-1015
Claire A LemieuxDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Miguel SkirzewskiRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0002-0980-0878
Meira M F MachadoRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0003-4619-5782
Joel C WattsTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-2604-2925
Jacob A McPhailStressMarq Biosciences, Victoria, BC, Canada.ORCID http://orcid.org/0000-0003-1490-808X
Ariel LouwrierStressMarq Biosciences, Victoria, BC, Canada.
Vania F PradoThe Graduate Program in Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0003-4994-6393
Lisa M SaksidaThe Graduate Program in Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0002-8416-8171
Marco A M PradoThe Graduate Program in Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0002-3028-5778
Timothy J BusseyThe Graduate Program in Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. tbussey@uwo.ca.ORCID http://orcid.org/0000-0002-3180-3709

Funding

Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology) 065772018Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) 159781
6 · The paper itself

Abstract

Translating findings from preclinical assessments of cognitive function relevant to synucleinopathies into successful clinical trials poses significant challenges. In this study, we examined the effectiveness of human-relevant touchscreen cognitive assessments in detecting the impact of α-synuclein pathology in a mouse model of synucleinopathy on the emergence of stimulus-response learning impairments as a potential cognitive biomarker. We generated two types of α-synuclein pre-formed fibrils, each displaying distinct biophysical characteristics in vitro and biochemical properties when stereotaxically injected in vivo. These two types of fibrils were capable of triggering impairments in stimulus-response learning in pre-motor, prodromal disease stages, akin to what is observed in humans with synucleinopathy. This work supports the use of touchscreen cognitive assessments in conjunction with robust preclinical rodent models for identifying targets and testing therapeutic strategies for synucleinopathic diseases.

Indexed as

alpha-SynucleinLearningSynucleinopathiesAnimalsBiomarkersDisease Models, AnimalHumansMaleMicealpha-SynucleinBiomarkers

Identifiers

PMID41513608
PMCPMC12804908

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.