ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2026
Transgenic expression of human CD47 on pig cells provides only partial protection against human macrophage-mediated destruction in human immune system mice.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Present Advances and Emerging Challenges in Kidney Xenotransplantation.Journal of clinical medicine · 2026Review
- Xenotransplantation Literature Update: January-June 2026.XenotransplantationReview
- Early Experimental Report of the First 8-Gene-Edited Pig-to-Rhesus Macaque Cardiac Xenotransplantation in China.XenotransplantationArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Tolerance induction would prevent xenograft rejection while avoiding high levels of immunosuppression. Mixed chimerism is an attractive approach to xenotolerance induction, as it tolerizes T, B, and natural killer cells. However, the species-specific interaction between CD47 and signal regulatory protein alpha is ineffective in the pig-to-human combination and may limit pig cell and organ engraftment. Prior studies showed that human CD47 (hCD47) expression on porcine cells can inhibit phagocytosis by primate macrophages. We have now tested the effect of hCD47 expression on the destruction of pig splenocytes in a human immune system (HIS) mouse model. Although the hCD47 transgene enhanced the survival of opsonized and nonopsonized porcine splenocytes in both HIS mice and nonreconstituted immunodeficient (NOD.Cg-Prkdc
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Registered trials
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