Evidence map›Paper›PMID 41513004›Full record

ArticleMucosal immunology2026

Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism.

Ulrich Membe Femoe, Fungai Musaigwa, Imani Nicolis, Li-Yin Hung, Camila Napuri, Chinwekele Uzoije, Heather L Rossi, Cailu Lin, Heidi Winters, Danielle R Reed and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ulrich Membe FemoeDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Fungai MusaigwaDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Imani NicolisDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Li-Yin HungDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Camila NapuriDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Chinwekele UzoijeDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Heather L RossiDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Cailu LinMonell Chemical Senses Center, Philadelphia, PA, USA.
Heidi WintersDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Danielle R ReedMonell Chemical Senses Center, Philadelphia, PA, USA.
Juan Manuel Inclan-RicoDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
De'Broski R HerbertDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA. Electronic address: dherbert@tulane.edu.

Funding

Perforin 2 controls unconventional cytokine release from mucosal APCU01AI163062 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2021 to 2025
$2.4M
Neuro-Immune mechanisms against skin-penetrating helminthsR01AI185041 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI De'Broski R Herbert · 2024 to 2026
$2.1M
Physiological roles of schistosome TRP ion channels with atypical pharmacologyR01AI123173 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2017 to 2021
$2.0M
Myeloid derived IL-33 controls Treg responses during parasite infectionR01AI164715 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2021 to 2024
$1.6M
Central role for skin sensory neurons in anti-helminth immunityR21AI171740 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R, ROSSI, HEATHER L · 2023 to 2024
$447k
Neuronal regulation of sinonasal Type 2 inflammationR21AI173476 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R, ROSSI, HEATHER L · 2023 to 2024
$447k
NIAID NIH HHS R01 AI123173NIAID NIH HHS R01 AI164715NIAID NIH HHS R01 AI185041NIAID NIH HHS R21 AI171740NIAID NIH HHS R21 AI173476NIAID NIH HHS U01 AI163062
6 · The paper itself

Abstract

Type 2 cytokine release promotes wound healing and helminth clearance, but it remains unclear whether group 2 innate lymphocytes (ILC2s) and T-helper 2 cells (T

Indexed as

Interleukin-17Lung InjuryLymphocytesNippostrongylusSerotoninStrongylida InfectionsTh2 CellsAnimalsDisease Models, AnimalImmunity, InnateLungMiceMice, KnockoutTrained ImmunityInterleukin-17SerotoninHelminthLungSerotoninTissue repairtrained ILC2Type 2 immunity

Identifiers

PMID41513004
PMCPMC13382995

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.