Evidence map›Paper›PMID 41512914›Full record

ArticleDevelopmental biology2026

Primary cilia and BBS4 are required for postnatal pituitary development.

Kathryn M Brewer, Katlyn K Brewer, Nicholas C Richardson, Jeremy F Reiter, Nicolas F Berbari, Mia J Konjikusic

Abstract read
In one paragraph

Article in Developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Kathryn M BrewerDepartment of Biology, Indiana University - Indianapolis, Indianapolis, IN, USA. Electronic address: katmbrew@iu.edu.
Katlyn K BrewerDepartment of Biology, Indiana University - Indianapolis, Indianapolis, IN, USA.
Nicholas C RichardsonDepartment of Biology, Indiana University - Indianapolis, Indianapolis, IN, USA. Electronic address: ncr7503@nyu.edu.
Jeremy F ReiterDepartment of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA. Electronic address: jeremy.reiter@ucsf.edu.
Nicolas F BerbariDepartment of Biology, Indiana University - Indianapolis, Indianapolis, IN, USA. Electronic address: nberbari@iu.edu.
Mia J KonjikusicDepartment of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA. Electronic address: mia.konjikusic@ucsf.edu.

Funding

DIABETES, ENDOCRINOLOGY &METABOLISM TRAINING PROGRAMT32DK007418 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 1986 to 2026
$14.3M
Hedgehog signaling at the cell's antenna: Smoothened and the primary ciliumR01AR054396 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeremy F Reiter · 2007 to 2026
$9.0M
How Hedgehog Contributes to Centrally Mediated Energy Homeostasis?R01DK114008 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Nicolas F Berbari, Jeremy F Reiter · 2018 to 2026
$3.3M
Understanding Ciliary Functions in Mammalian DevelopmentR01HD089918 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REITER, JEREMY F, YODER, BRADLEY K. · 2017 to 2021
$3.0M
Cilia-mediated Proliferation in Hypothalamic TanycytesF31DK142351 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Kathryn M Brewer · 2025 to 2026
$82k
NIAMS NIH HHS R01 AR054396NICHD NIH HHS R01 HD089918NIDDK NIH HHS F31 DK142351NIDDK NIH HHS R01 DK114008NIDDK NIH HHS T32 DK007418
6 · The paper itself

Abstract

Primary cilia orchestrate several signaling pathways, and their disruption results in pleiotropic disorders called ciliopathies. Bardet-Beidl syndrome (BBS), one ciliopathy, provides insights into cilia function in many tissues. Using a mouse model of BBS, Bbs4 knockout (Bbs4

Indexed as

CiliaMicrotubule-Associated ProteinsPituitary GlandAnimalsBardet-Biedl SyndromeHedgehog ProteinsMiceMice, KnockoutSignal TransductionStem CellsBBS4 protein, mouseHedgehog ProteinsMicrotubule-Associated ProteinsBardet-Biedl syndromeCiliaCiliopathiesGonadotrophsPituitary

Identifiers

PMID41512914
PMCPMC12889902

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.