ArticleCell reports methods2026
Generation of thymus-reconstituting T cell progenitors from human pluripotent stem cells.
Article in Cell reports methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Protocol to generate human T cell progenitors that repopulate the thymus.STAR protocols · 2026Article
- Generation of therapeutic T cells from human induced pluripotent stem cells.Inflammation and regeneration · 2026Review
- Human pluripotent stem cell-derived innate and adaptive immune cells for cancer immunotherapy.Cell stem cell · 2026Review
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Authors and funding
9 authors.
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Abstract
Generating a large number of progenitors that can repopulate the immune system of a recipient is one of the key steps toward efficient cancer immunotherapy. Here, we describe the engineering of T cell progenitors capable of direct and long-term reconstitution of the thymus. In the thymus, human pluripotent stem cell (hPSC)-derived progenitor T cells (pro-T cells) developed into single-positive human T cells that entered circulation and settled in the spleen. Single-cell transcriptome analysis of differentiating hPSCs attested to the emergence of cells that displayed the transcription signature of the early T cell progenitors. Comparative transcription profiling revealed the similarity of the hPSC-pro-T cells with the early T cell precursors of the human thymus. The in vitro generation of T cell progenitors provides a powerful model for studying the molecular mechanisms of human T cell development and improves the perspectives for T cell regenerative medicine, including chimeric antigen receptor T (CAR-T) cell therapies.
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