Substituent size versus metal binding of inhibitors with variants of influenza endonuclease.

Alysia J Kohlbrand, Ryjul W Stokes, Banumathi Sankaran, Seth M Cohen

Abstract read

In one paragraph

Article in Journal of inorganic biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alysia J KohlbrandDepartment of Chemistry and Biochemistry, University of California, La Jolla, CA 92093, USA.

Ryjul W StokesDepartment of Chemistry and Biochemistry, University of California, La Jolla, CA 92093, USA.

Banumathi SankaranThe Berkeley Center for Structural Biology, Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Seth M CohenDepartment of Chemistry and Biochemistry, University of California, La Jolla, CA 92093, USA. Electronic address: scohen@ucsd.edu.

Funding

Metal-binding Isosteres for Influenza Endonuclease Inhibitors and BeyondR01AI149444 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SETH M COHEN · 2020 to 2026

$2.3M

NIAID NIH HHS R01 AI149444

6 · The paper itself

Abstract

The influenza virus causes a significant burden of illness each year. Although vaccination is the most effective method to prevent seasonal influenza infection, viral escape mechanisms make vaccine composition difficult to predict. Antivirals are crucial for decreasing rates of morbidity and mortality from influenza viral infection. The newest anti-influenza drugs target the RNA-dependent RNA polymerase acidic N-terminal (PA

Indexed as

Antiviral AgentsEndonucleasesEnzyme InhibitorsOrthomyxoviridaeRNA-Dependent RNA PolymeraseViral ProteinsCrystallography, X-RayModels, MolecularAntiviral AgentsEndonucleasesEnzyme InhibitorsRNA-Dependent RNA PolymeraseViral ProteinsEndonucleaseInfluenzaInhibitorMetal-binding pharmacophoreMutants

Identifiers

PMID41512630

DOI10.1016/j.jinorgbio.2025.113210

PMCPMC13298843

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.