Observational studyNeurology2026
Autoregulation-Guided Blood Pressure Targets After Stroke Thrombectomy: Impact on Secondary Brain Injury and Neurologic Outcomes.
Observational study in Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Mid-term systolic BP variability beyond 24 h after successful recanalization predicts poor outcomes following ischemic stroke.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Identification of vital sign trajectory phenotypes and treatment response heterogeneity in critically ill patients with ischemic stroke: A multicenter study with external validation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Endovascular thrombectomy for acute ischemic stroke: evolving patient selection, procedural strategies, and adjunctive therapies.Frontiers in neurology · 2026Review
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
BACKGROUND AND
objectivesThe optimal blood pressure (BP) target after endovascular thrombectomy (EVT) remains elusive. The aim of our study was to assess the relationship between individualized autoregulation-based BP thresholds, secondary brain injury, and functional outcomes.
methodsWe conducted a prospective observational study of patients with acute ischemic stroke who underwent EVT. Simultaneous recordings of arterial BP and near-infrared spectroscopy were used to continuously monitor each patient's limits of autoregulation for up to 24 hours. Time outside limits of autoregulation was correlated with short-term clinical end points, radiographic biomarkers of secondary brain injury, and functional outcomes.
resultsPersonalized BP targets were successfully computed in 199 patients. Percent time outside limits of autoregulation was independently associated with early neurologic deterioration (OR 1.2, 95% CI 1.1-1.4, DISCUSSION: Deviations from personalized BP targets were associated with an increased risk of secondary brain injury and worse functional outcomes. The study proposes autoregulation-oriented BP management as a promising strategy for improving recovery after ischemic stroke.
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