Evidence map›Paper›PMID 41512067›Full record

ArticleScience advances2026

Enantioselective rapid assembly of bis-heterocycles by sequential palladium-catalyzed aza-Heck cyclization coupling reaction.

Lei Wang, Shuaijie Wu, Wenyu Zhang, Shuting Zhang, Jieya Dong, Weiming Hu, Chengcheng Zhou, Liuzhou Gao, Liejin Zhou, Junliang Zhang

Abstract read
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In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lei WangSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.ORCID 0000-0002-8792-0234
Shuaijie WuSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.ORCID 0009-0000-7886-3875
Wenyu ZhangSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Shuting ZhangSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Jieya DongSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Weiming HuSchool of Environmental and Chemical Engineering, Jiangsu Ocean University, Lianyungang 222005, Jiangsu, China.ORCID 0000-0002-0157-1089
Chengcheng ZhouSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.ORCID 0000-0002-4351-4517
Liuzhou GaoSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.ORCID 0000-0002-5409-8248
Liejin ZhouLaboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua, Zhejiang, China.ORCID 0000-0003-3929-2525
Junliang ZhangSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.ORCID 0000-0002-4636-2846

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A highly efficient palladium-catalyzed enantioselective aza-Heck-catalyzed cyclization coupling reaction of alkyne-tethered oxygen- and nitrogen-centered nucleophiles is reported. This protocol enables versatile access to chiral isoindolinone-linked benzofuran and indole bis-heterocyclic derivatives bearing a quaternary stereogenic center in good yields with high enantioselectivities. A sterically demanding, electron-rich (S)-(+)-1,1'-Bi-2-naphthol (BINOL)-derived phosphoramidite ligand provides excellent control over both chemoselectivity and enantioselectivity. Density functional theory calculations were used to elucidate the reaction mechanism and the origin of enantioselectivity. Moreover, these bis-heterocycles exhibited promising antimicrobial activity.

Identifiers

PMID41512067
PMCPMC12787585

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