Evidence map›Paper›PMID 41512059›Full record

ArticleScience advances2026

Three-component synthesis of β-thio tertiary alkylamines from simple alkenes via S

Hongyu Wang, Ting Wang, Yang Li, Qianyu He, Wenxuan Ma, Xinyu Guan, Yifei Li, Yongli Bao, Yongyun Zhao, Qian Zhang and 3 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hongyu WangNational Engineering Laboratory for Druggable Gene and Protein Screening, College of Life Science, Northeast Normal University, Changchun 130024, P. R. China.ORCID 0009-0004-1382-3919
Ting WangKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Key Laboratory of Organosilicon Material Technology of Zhejiang Province, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0002-6871-470X
Yang LiNational Engineering Laboratory for Druggable Gene and Protein Screening, College of Life Science, Northeast Normal University, Changchun 130024, P. R. China.ORCID 0009-0003-5401-0511
Qianyu HeNational Engineering Laboratory for Druggable Gene and Protein Screening, College of Life Science, Northeast Normal University, Changchun 130024, P. R. China.ORCID 0000-0001-9810-2408
Wenxuan MaJilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis and Institute of Functional Material Chemistry, Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China.ORCID 0009-0003-3639-7302
Xinyu GuanJilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis and Institute of Functional Material Chemistry, Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China.
Yifei LiJilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis and Institute of Functional Material Chemistry, Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China.ORCID 0000-0002-3167-7175
Yongli BaoNational Engineering Laboratory for Druggable Gene and Protein Screening, College of Life Science, Northeast Normal University, Changchun 130024, P. R. China.ORCID 0000-0002-5972-1983
Yongyun ZhaoNational Engineering Laboratory for Druggable Gene and Protein Screening, College of Life Science, Northeast Normal University, Changchun 130024, P. R. China.ORCID 0000-0002-0360-8682
Qian ZhangJilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis and Institute of Functional Material Chemistry, Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China.ORCID 0000-0002-3136-841X
Neil VasdevAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON M5T 1R8, Canada.ORCID 0000-0002-2087-5125
Chao ZhengAzrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON M5T 1R8, Canada.ORCID 0000-0002-2179-8096
Junkai FuNational Engineering Laboratory for Druggable Gene and Protein Screening, College of Life Science, Northeast Normal University, Changchun 130024, P. R. China.ORCID 0000-0002-7714-8818

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alkene difunctionalization via electrophilic aminyl radical cations offers a straightforward route to complex tertiary alkylamines widely occurring in biologically active molecules. However, only a limited variety of third reaction components have been hitherto introduced because of the challenges in capturing transient C(sp

Identifiers

PMID41512059
PMCPMC12787521

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.